PLoS One:下尿路感染案例-对照以及相关抗生素和发展为前列腺癌风险的研究

2018-04-16 AlexYang MedSci原创

最近,有研究人员进行了旨在调查下尿路感染与相关抗生素和随后发展为前列腺癌风险之间的相关性的研究。研究的数据来源于瑞典PCBaSe 3.0,研究人员进行的是相匹配的案例-对照研究(包括8762个案例和43806个对照)。研究发现,下尿路感染不影响前列腺癌风险。然而,与不具有下尿路感染的男性相比,具有下尿路感染或者在前列腺癌之前第一次使用抗生素6-12个月的均与前列腺癌风险的增加相关(分别为OR: 1

最近,有研究人员进行了旨在调查下尿路感染与相关抗生素和随后发展为前列腺癌风险之间的相关性的研究。研究的数据来源于瑞典PCBaSe 3.0,研究人员进行的是相匹配的案例-对照研究(包括8762个案例和43806个对照)。

研究发现,下尿路感染不影响前列腺癌风险。然而,与不具有下尿路感染的男性相比,具有下尿路感染或者在前列腺癌之前第一次使用抗生素6-12个月的均与前列腺癌风险的增加相关(分别为OR: 1.50, 95% CI: 1.23-1.82和1.96, 1.71-2.25)。与那些使用药物中没有抗生素的相比,使用不少于10中抗生素的男性发展为前列腺癌的风险要少15%(OR: 0.85, 95% CI: 0.78-0.91)。

最后,研究人员指出,前列腺癌与泌尿道感染诊断或者频率没有相关性,但是在发展为前列腺癌之前短时间内诊断的下尿路感染或者抗生素的使用相关。这些数据很可能可以由检测偏倚来进行解释,这也抢掉了当研究前列腺癌风险因子时,诊断数据的重要性。

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    2018-11-11 amyloid
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    2018-07-25 sjq027
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