Am J Gastroenterol:肠炎患者肠道肿瘤风险因素研究

2017-05-29 zhangfan MedSci原创

研究认为,免疫抑制及抗TNF药物不会增加炎症性肠病患者肠道肿瘤风险,高龄及吸烟是该类患者肿瘤高风险因素

近日研究人员对炎症性肠炎患者肠外肿瘤风险因素进行了相关研究。研究主要针对炎症性肠病IBD)中肠外肿瘤(EC)的患病率和分布以及评估免疫抑制剂和抗肿瘤坏死因子药物对EC的影响。

该研究为一项队列观察性研究,入选标准为IBD患者,排除在IBD确诊前患EC的患者以及之前接受过除糖皮质激素,巯嘌呤,甲氨蝶呤或抗肿瘤坏死因子以外的免疫抑制治疗患者。

共11011名患者满足要求开展中位随访98周的研究。5304人(48%)的患者之前服用过免疫抑制剂或抗TNF药物,其中45.8%服用硫嘌呤,4.7%服用甲氨蝶呤,21.6%接受抗TNF药物。研究中EC的发生率为3.6%。在多变量分析发现,年龄(HR = 1.05,95% CI,1.04 - 1.06)并有吸烟史(HR= 1.47,95%,CI,1.10 - 1.80)是唯一的高EC风险变量。

研究认为,免疫抑制及抗TNF药物不会增加炎症性肠病患者肠道肿瘤风险,高龄及吸烟是该类患者肿瘤高风险因素。

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  5. 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    2018-02-25 许安
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    2017-06-03 日月生辉

    到说的是肠外肿瘤还是肠道肿瘤?

    0

  7. 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content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon May 29 23:08:28 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204045, encodeId=524f204045ae, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Mon May 29 15:03:36 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204036, encodeId=7f28204036bb, content= 吸烟的危害!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKT9Tk01eiaQ9QHMuAiaO48A8OmtM9WGtiatxfLRdPQAmL2UxxjUB0RQDGJjgvWkcaZ8uW38Z4JFq4sw/132, createdBy=f5a62063089, createdName=临风淑玉, createdTime=Mon May 29 14:10:37 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-30 ylzr123

    认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦

    0

  8. 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content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon May 29 23:08:28 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204045, encodeId=524f204045ae, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Mon May 29 15:03:36 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204036, encodeId=7f28204036bb, content= 吸烟的危害!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKT9Tk01eiaQ9QHMuAiaO48A8OmtM9WGtiatxfLRdPQAmL2UxxjUB0RQDGJjgvWkcaZ8uW38Z4JFq4sw/132, createdBy=f5a62063089, createdName=临风淑玉, createdTime=Mon May 29 14:10:37 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-29 luominglian113

    学习了,谢谢分享

    0

  9. 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content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon May 29 23:08:28 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204045, encodeId=524f204045ae, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Mon May 29 15:03:36 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204036, encodeId=7f28204036bb, content= 吸烟的危害!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKT9Tk01eiaQ9QHMuAiaO48A8OmtM9WGtiatxfLRdPQAmL2UxxjUB0RQDGJjgvWkcaZ8uW38Z4JFq4sw/132, createdBy=f5a62063089, createdName=临风淑玉, createdTime=Mon May 29 14:10:37 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-29 dhzzm

    学习了分享了

    0

  10. 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attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKT9Tk01eiaQ9QHMuAiaO48A8OmtM9WGtiatxfLRdPQAmL2UxxjUB0RQDGJjgvWkcaZ8uW38Z4JFq4sw/132, createdBy=f5a62063089, createdName=临风淑玉, createdTime=Mon May 29 14:10:37 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-29 临风淑玉

    吸烟的危害!

    0

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