Int J Cardiol:贫血对亚临床心肌损伤和心血管死亡率的影响存在性别差异!

2017-11-12 xing.T MedSci原创

由此可见,在男性受试者中,贫血是全因死亡率、心血管死亡率和临床心肌损伤的独立预测因子,但在女性受试者中并不是这样。

贫血已被证实会导致心血管疾病恶化。然而,目前尚不清楚贫血对亚临床心肌损伤和心血管死亡的影响是否存在性别差异。近日,心血管领域权威杂志International Journal of Cardiology上针对这一问题发表了一篇研究文章。

在一项基于年度健康检查的社区前瞻性队列研究中。研究人员测量了基线时无心血管疾病的受试者(n=3111)血清中心脏型脂肪酸结合蛋白(H-FABP)的水平,这是心肌损伤的标志物,和血细胞计数。

在基线时存在贫血的343例(11%)受试者。H-FABP水平与男性血红蛋白浓度呈负相关,而在女性受试者中没有观察到这样的相关性,不论绝经状态。心肌损伤的发生率(H-FABP≥4.3ng/ml)在男性贫血患者明显高于无贫血的男性,不论贫血类型(小细胞、正常细胞和大红细胞性贫血)。多因素logistic回归分析显示,在调整混杂因素后,贫血是心肌损伤的独立预测因子。在10年的随访期间,共有204人死亡,其中57人死于心血管疾病。Kaplan–Meier分析表明,贫血男性患者心血管死亡率高于无贫血者。然而,贫血与女性患者的心血管死亡率无关。对混杂因素进行调整后,多因素Cox比例风险分析显示贫血是全因死亡率和心血管死亡率的独立预测因素。

由此可见,在男性受试者中,贫血是全因死亡率、心血管死亡率和临床心肌损伤的独立预测因子,但在女性受试者中并不是这样。

原始出处:


Yuki Hondaa, et al. Gender differences in the impact of anemia on subclinical myocardial damage and cardiovascular mortality in the general population: The Yamagata (Takahata) study.International Journal of Cardiology.2017. https://doi.org/10.1016/j.ijcard.2017.11.019

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encryptionId=ab025182080, topicName=心血管死亡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0fb814514579, createdName=huperzia, createdTime=Mon Nov 13 23:21:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260995, encodeId=97f926099538, content=讲解的非常好,值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Nov 13 13:20:03 CST 2017, time=2017-11-13, status=1, ipAttribution=)]
    2017-11-25 虈亣靌

    好好看下.内容丰富

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Nov 18 13:26:14 CST 2017, time=2017-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=261230, encodeId=407a261230d4, content=是很好的学习材料.不错.以后会多学习., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Nov 14 10:35:17 CST 2017, time=2017-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310050, encodeId=d523131005095, content=<a href='/topic/show?id=ddd95126e4e' target=_blank style='color:#2F92EE;'>#心肌损伤#</a>, 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encryptionId=ab025182080, topicName=心血管死亡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0fb814514579, createdName=huperzia, createdTime=Mon Nov 13 23:21:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260995, encodeId=97f926099538, content=讲解的非常好,值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Nov 13 13:20:03 CST 2017, time=2017-11-13, status=1, ipAttribution=)]
    2017-11-18 虈亣靌

    谢谢分享知识

    0

  5. 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encryptionId=ab025182080, topicName=心血管死亡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0fb814514579, createdName=huperzia, createdTime=Mon Nov 13 23:21:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260995, encodeId=97f926099538, content=讲解的非常好,值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Nov 13 13:20:03 CST 2017, time=2017-11-13, status=1, ipAttribution=)]
    2017-11-14 李东泽

    是很好的学习材料.不错.以后会多学习.

    0

  6. 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  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Nov 18 13:26:14 CST 2017, time=2017-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=261230, encodeId=407a261230d4, content=是很好的学习材料.不错.以后会多学习., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Nov 14 10:35:17 CST 2017, time=2017-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310050, encodeId=d523131005095, content=<a href='/topic/show?id=ddd95126e4e' target=_blank style='color:#2F92EE;'>#心肌损伤#</a>, 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createdTime=Mon Nov 13 23:21:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418487, encodeId=3a76141848ed9, content=<a href='/topic/show?id=772e5182166' target=_blank style='color:#2F92EE;'>#心血管死亡率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51821, encryptionId=772e5182166, topicName=心血管死亡率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26613379061, createdName=smallant2003, createdTime=Mon Nov 13 23:21:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1554185, encodeId=c69d1554185a7, content=<a href='/topic/show?id=ab025182080' target=_blank style='color:#2F92EE;'>#心血管死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51820, encryptionId=ab025182080, topicName=心血管死亡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0fb814514579, createdName=huperzia, createdTime=Mon Nov 13 23:21:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260995, encodeId=97f926099538, content=讲解的非常好,值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Nov 13 13:20:03 CST 2017, time=2017-11-13, status=1, ipAttribution=)]
    2017-11-13 虈亣靌

    讲解的非常好,值得学习

    0

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