CLIN CANCER RES:肺癌TP53及KRAS突变预测阻断PD-1免疫治疗反应

2017-07-02 MedSci MedSci原创

临床研究表明在非小细胞肺癌(NSCLC)中靶向PD-1及PD-L1信号通路治疗具有前景,但是能够预测对检查点抑制剂治疗有反应的患者特征尚缺乏研究。CLIN CANCER RES近期发表了一篇文章,研究TP53及KRAS突变预测PD-1免疫治疗反应。

临床研究表明在非小细胞肺癌(NSCLC)中靶向PD-1及PD-L1信号通路治疗具有前景,但是能够预测对检查点抑制剂治疗有反应的患者特征尚缺乏研究。CLIN CANCER RES近期发表了一篇文章,研究TP53及KRAS突变预测PD-1免疫治疗反应。作者通过公共数据库及内部数据库进行了基因组学、转录组学、蛋白组学及临床数据的分析。研究发现TP53突变显着增加免疫检查点表达,活化效应T以及增加干扰素γ水平。更重要的是,TP53/KRAS共突变亚组表型出显着的PD-L1表达并且PD-L1+/CD8A+比例最高。针对可能分子机制的进一步研究表明TP53或KRAS突变会改变与细胞周期调节、DNA复制及损伤修复有关基因的表达。通过公开的免疫治疗临床试验及作者所在中心内部的回顾性分析进一步确认TP53或KRAS突变患者,尤其是同时存在TP53/KRAS突变的患者接受PD-1抑制剂治疗具有显着的临床获益。文章最后认为,肺癌TP53及KRAS突变可以作为指导抗PD-1/PD-L1免疫治疗的预测因素。原始出处:Zhong-Yi Dong,Wen-Zhao Zhong,et al.Potential Pre

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    2017-07-20 1e10c84am36(暂无匿称)

    文章不错,谢谢分享

    0

  3. 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  5. 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href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13627, encryptionId=9d861362e53, topicName=p53)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Tue Jul 04 11:05:00 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458434, encodeId=f9db145843498, content=<a href='/topic/show?id=50a81e6869e' target=_blank style='color:#2F92EE;'>#TP53#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17686, encryptionId=50a81e6869e, topicName=TP53)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d276073420, createdName=zblhy, createdTime=Tue Jul 04 11:05:00 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585295, encodeId=1dd4158529570, content=<a href='/topic/show?id=792b15145a6' target=_blank style='color:#2F92EE;'>#RAS突变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15145, encryptionId=792b15145a6, topicName=RAS突变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f2c17156536, createdName=bioon7, createdTime=Tue Jul 04 11:05:00 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218277, encodeId=55ae2182e7a8, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon Jul 03 23:58:39 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218049, encodeId=35582180496e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NebL6HUuazlWRDicKU30ib7MWct2QQNWiao1ntOx2x5WUHGVw7R8NBdVuXbznuDsHKg3ImrnRyHGr8WSmKTnycicXEf/0, createdBy=bcd81373695, createdName=dpbl_zlh, createdTime=Mon Jul 03 08:05:27 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-04 yinhl1978
  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585295, encodeId=1dd4158529570, content=<a href='/topic/show?id=792b15145a6' target=_blank style='color:#2F92EE;'>#RAS突变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15145, encryptionId=792b15145a6, topicName=RAS突变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f2c17156536, createdName=bioon7, createdTime=Tue Jul 04 11:05:00 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218277, encodeId=55ae2182e7a8, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon Jul 03 23:58:39 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218049, encodeId=35582180496e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NebL6HUuazlWRDicKU30ib7MWct2QQNWiao1ntOx2x5WUHGVw7R8NBdVuXbznuDsHKg3ImrnRyHGr8WSmKTnycicXEf/0, createdBy=bcd81373695, createdName=dpbl_zlh, createdTime=Mon Jul 03 08:05:27 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-04 zhishijing
  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218049, encodeId=35582180496e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NebL6HUuazlWRDicKU30ib7MWct2QQNWiao1ntOx2x5WUHGVw7R8NBdVuXbznuDsHKg3ImrnRyHGr8WSmKTnycicXEf/0, createdBy=bcd81373695, createdName=dpbl_zlh, createdTime=Mon Jul 03 08:05:27 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-04 zblhy
  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218049, encodeId=35582180496e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NebL6HUuazlWRDicKU30ib7MWct2QQNWiao1ntOx2x5WUHGVw7R8NBdVuXbznuDsHKg3ImrnRyHGr8WSmKTnycicXEf/0, createdBy=bcd81373695, createdName=dpbl_zlh, createdTime=Mon Jul 03 08:05:27 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-04 bioon7
  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585295, encodeId=1dd4158529570, content=<a href='/topic/show?id=792b15145a6' target=_blank style='color:#2F92EE;'>#RAS突变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15145, encryptionId=792b15145a6, topicName=RAS突变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f2c17156536, createdName=bioon7, createdTime=Tue Jul 04 11:05:00 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218277, encodeId=55ae2182e7a8, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon Jul 03 23:58:39 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218049, encodeId=35582180496e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NebL6HUuazlWRDicKU30ib7MWct2QQNWiao1ntOx2x5WUHGVw7R8NBdVuXbznuDsHKg3ImrnRyHGr8WSmKTnycicXEf/0, createdBy=bcd81373695, createdName=dpbl_zlh, createdTime=Mon Jul 03 08:05:27 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-03 luominglian113

    学习了,谢谢分享

    0

  10. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218049, encodeId=35582180496e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NebL6HUuazlWRDicKU30ib7MWct2QQNWiao1ntOx2x5WUHGVw7R8NBdVuXbznuDsHKg3ImrnRyHGr8WSmKTnycicXEf/0, createdBy=bcd81373695, createdName=dpbl_zlh, createdTime=Mon Jul 03 08:05:27 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-03 dpbl_zlh

    学习了

    0

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NEJM:Nivolumab一线应用对生存的改善不优于标准化疗(CheckMate 026研究)

美国俄亥俄州立大学综合癌症中心David P. Carbone等报告,针对初治的Ⅳ期非小细胞肺癌(NSCLC)患者、或PD-L1表达≥5%的复发性患者,Nivolumab对比含铂化疗并未显著改善患者的无进展生存期(PFS),且两种方案治疗后患者的总生存(OS)获益相近;但Nivolumab的安全性优于化疗,且未见新发的或超出预期的安全事件。(N Engl J Med. 2017;376:241

Thorax:AHRR(cg05575921)低甲基化标记吸烟行为、发病率和死亡率

AHRR(cg05575921)低甲基化是吸烟行为的标记,为未来吸烟相关的发病率和死亡率提供了潜在的临床相关预测指标。

Nat Immunol:一种免疫细胞或能预测肺癌免疫治疗获益人群

近日,科学家发现了一种新型免疫细胞,可以预测哪些肺癌患者将从免疫治疗中获益最多。南安普敦大学和加利福尼亚州La Jolla过敏与免疫研究所的研究人员发现,具有大量特定类型免疫T细胞(称为组织常驻记忆T细胞)的肺癌患者生存率高34%。