JAMA Psychiatry:剖宫产还会增加强迫症风险?

2016-10-06 Mechront 译 MedSci原创

最近的研究结果表明,孕期每天吸烟至少10支或以上、臀位、剖宫产、早产和其他围产期因素,与强迫性神经症(OCD)风险的增加有关。 来自瑞典卡罗林斯卡研究所的Gustaf Brander为了评估OCD的潜在围产期危险因素,进行了一项以人群为基础的出生队列研究,纳入了2421284名于1973和1996年之间,出生在瑞典的儿童;随访到2013年。 总的来说,17305名参与者被诊断为OCD;

最近的研究结果表明,孕期每天吸烟至少10支或以上、臀位、剖宫产、早产和其他围产期因素,与强迫性神经症(OCD)风险的增加有关。

来自瑞典卡罗林斯卡研究所的Gustaf Brander为了评估OCD的潜在围产期危险因素,进行了一项以人群为基础的出生队列研究,纳入了2421284名于1973和1996年之间,出生在瑞典的儿童;随访到2013年。

总的来说,17305名参与者被诊断为OCD;首次诊断的平均年龄为23.4岁。

与OCD风险增加的相关因素包括:孕期每天吸烟至少10支或以上(HR = 1.27; 95% CI, 1.02-1.58)、臀位(HR = 1.35; 95% CI, 1.06-1.71)、剖宫产(HR = 1.17; 95% CI, 1.01-1.34)、早产(HR = 1.24; 95% CI, 1.07-1.43)、出生体重在1501克和2500克之间(HR = 1.3; 95% CI, 1.05-1.62)、出生体重在2501克至3500克之间(HR = 1.08; 95% CI, 1.01-1.16)、胎龄大(HR = 1.23; 95% CI, 1.05-1.45)、出生后5分钟阿普加评分提示新生儿窘迫(HR = 1.5; 95% CI, 1.07-2.09)。

校正混杂因素后,这些联系仍存在。

更小的胎龄(HR = 1.61; 95% CI, 1.35-1.91)和更低的出生体重(HR = 1.1; 95% CI, 1-1.21),OCD的风险更高。

研究人员发现,围生期事件数量与OCD的风险之间还存在剂量-反应关系;事件数为1时,OCD的HR值为1.11 (95% CI, 1.07-1.15);事件数≥5时,OCD的HR值为1.51 (95% CI, 1.18-1.94)。

原始出处:

Perinatal complications associated with increased risk for OCD.Healio.October 5, 2016

Brander G, et al.Association of Perinatal Risk Factors With Obsessive-Compulsive Disorder. JAMA Psychiatry. 2016;doi:10.1001/jamapsychiatry.2016.2095.

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    2017-05-04 laoli

    学习了,谢谢分享!

    0

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    2016-10-12 1e10c84am36(暂无匿称)

    好文章,受益

    0

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    2016-10-07 知难而进

    继续关注!

    0

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    2016-10-07 知难而进

    谢谢分享!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=193815, encodeId=b9ab1938156c, content=学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Thu May 04 20:45:50 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792017, encodeId=fd7f1e9201707, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Nov 07 10:43:00 CST 2016, time=2016-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146362, encodeId=800a146362de, content=好文章,受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Oct 12 09:39:41 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141385, encodeId=b37e141385a4, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Fri Oct 07 07:26:29 CST 2016, time=2016-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141384, encodeId=68d314138400, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Fri Oct 07 07:26:22 CST 2016, time=2016-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141108, encodeId=cc21141108df, content=不会吧!, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Thu Oct 06 15:49:46 CST 2016, time=2016-10-06, status=1, ipAttribution=)]
    2016-10-06 榄枷檬

    不会吧!

    0

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