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Heart：主动脉瓣钙化与冠脉事件和心血管疾病相关

2014-02-18 佚名 不详

主动脉瓣钙化冠脉事件心血管疾病
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德国一项研究表明，主动脉瓣钙化(AVC)与冠脉事件和心血管疾病事件具有相关性，并且独立于传统危险因素，但主动脉瓣钙化不改善心血管事件的预测。。论文2月5日在线发表于《心脏》(Heart)。【原文下载】 此项研究共纳入3944例年龄为59.3±7.7岁的受试者，并在9.1±1.9年间对冠脉事件、卒中和心血管疾病进行了评估。利用CT扫描对AVC进行定量，并利用Cox比例风

德国一项研究表明，主动脉瓣钙化(AVC)与冠脉事件和心血管疾病事件具有相关性，并且独立于传统危险因素，但主动脉瓣钙化不改善心血管事件的预测。。论文2月5日在线发表于《心脏》(Heart)。【原文下载】

此项研究共纳入3944例年龄为59.3±7.7岁的受试者，并在9.1±1.9年间对冠脉事件、卒中和心血管疾病进行了评估。利用CT扫描对AVC进行定量，并利用Cox比例风险回归和Harrell‘s C评估AVC在传统危险因素和冠脉钙化（CAC）之外的预测价值。

结果显示，随访期间138例受试者（3.5%）出现冠脉事件，101例（2.6%）出现卒中，257例出现心血管疾病。在AVC>0和AVC=0的受试者中，冠脉事件的发生率分别为8.0%和3.0%（P<0.001），心血管疾病发生率分别为13.0%和5.7%（P<0.001）。事件发生率随AVC评分升高而显著增加。对Framingham危险因素进行校正之后，高AVC评分仍与冠脉事件（HR 2.21）和心血管疾病（HR 1.67）显著相关。对CAC行更进一步校正之后，HR有所降低。将ACV添加至包含有传统危险因素和CAC的模型之后，冠脉事件和心血管疾病的Harrell's C指数未增加。

原始出处：

Kälsch H, Lehmann N, Mahabadi AA, Bauer M, Kara K, Hüppe P, Moebus S, Möhlenkamp S, Dragano N, Schmermund A, Stang A, Jöckel KH, Erbel R; on behalf of the Investigator Group of the Heinz Nixdorf Recall Study.Beyond Framingham risk factors and coronary calcification: does aortic valve calcification improve risk prediction? The Heinz Nixdorf Recall Study.Heart. 2014 Feb 5. doi: 10.1136/heartjnl-2013-305205.【原文下载】

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    2014-05-31 ms3117646317107274

    #冠脉事件#

    0

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    2014-02-20 hittouch

    #主动脉瓣#

    0

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    2014-02-20 zhaojie88

    #ART#

    0

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    2014-02-20 circumcision

    #主动脉#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1634817, encodeId=b3f9163481e04, content=<a href='/topic/show?id=dbcc30940cb' target=_blank style='color:#2F92EE;'>#冠脉事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30940, encryptionId=dbcc30940cb, topicName=冠脉事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccfc22296342, createdName=ms3117646317107274, createdTime=Sat May 31 07:23:00 CST 2014, time=2014-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332352, encodeId=9181133235204, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355827, encodeId=ac7c135582e25, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414965, encodeId=b1c3141496591, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497814, encodeId=17cc149e814de, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562207, encodeId=9624156220e22, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591638, encodeId=391e1591638a4, content=<a href='/topic/show?id=9d632320817' target=_blank style='color:#2F92EE;'>#主动脉瓣钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23208, encryptionId=9d632320817, topicName=主动脉瓣钙化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d6717964407, createdName=respect, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=)]
    2014-02-20 仁者大医

    #血管疾病#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1634817, encodeId=b3f9163481e04, content=<a href='/topic/show?id=dbcc30940cb' target=_blank style='color:#2F92EE;'>#冠脉事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30940, encryptionId=dbcc30940cb, topicName=冠脉事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccfc22296342, createdName=ms3117646317107274, createdTime=Sat May 31 07:23:00 CST 2014, time=2014-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332352, encodeId=9181133235204, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355827, encodeId=ac7c135582e25, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414965, encodeId=b1c3141496591, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497814, encodeId=17cc149e814de, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562207, encodeId=9624156220e22, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591638, encodeId=391e1591638a4, content=<a href='/topic/show?id=9d632320817' target=_blank style='color:#2F92EE;'>#主动脉瓣钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23208, encryptionId=9d632320817, topicName=主动脉瓣钙化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d6717964407, createdName=respect, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=)]
    2014-02-20 爆笑小医

    #HEART#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1634817, encodeId=b3f9163481e04, content=<a href='/topic/show?id=dbcc30940cb' target=_blank style='color:#2F92EE;'>#冠脉事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30940, encryptionId=dbcc30940cb, topicName=冠脉事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccfc22296342, createdName=ms3117646317107274, createdTime=Sat May 31 07:23:00 CST 2014, time=2014-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332352, encodeId=9181133235204, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355827, encodeId=ac7c135582e25, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414965, encodeId=b1c3141496591, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497814, encodeId=17cc149e814de, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562207, encodeId=9624156220e22, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591638, encodeId=391e1591638a4, content=<a href='/topic/show?id=9d632320817' target=_blank style='color:#2F92EE;'>#主动脉瓣钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23208, encryptionId=9d632320817, topicName=主动脉瓣钙化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d6717964407, createdName=respect, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=)]
    2014-02-20 respect

    #主动脉瓣钙化#

    0