Tissue Eng Part A:磷酸钙与钛相比哪个更适合骨组织工程

2018-11-01 MedSci MedSci原创

骨组织工程支架的添加制造将成为日后个性化骨组织工程的关键要素。几种增材制造工艺基于挤出,其中长丝的沉积将产生三维晶格结构。近期,我们研究了通过激光烧结钛实现的骨组织工程的各种晶格结构。 在这项工作中,我们使用基于光刻的陶瓷制造晶格结构来生产磷酸三钙(TCP)的支架,并将它们在体内与用相同的计算机辅助设计数据制造的全等钛支架进行比较,以寻找基于材料的骨质差异愈合。结果显示,在兔颅骨中非临界尺寸

骨组织工程支架的添加制造将成为日后个性化骨组织工程的关键要素。几种增材制造工艺基于挤出,其中长丝的沉积将产生三维晶格结构。近期,我们研究了通过激光烧结钛实现的骨组织工程的各种晶格结构。

在这项工作中,我们使用基于光刻的陶瓷制造晶格结构来生产磷酸三钙(TCP)的支架,并将它们在体内与用相同的计算机辅助设计数据制造的全等钛支架进行比较,以寻找基于材料的骨质差异愈合。结果显示,在兔颅骨中非临界尺寸缺陷的4周期间,具有相同微结构的两个支架在骨再生和骨缺损的桥接方面表现同样良好。只有当基于TCP的支架掺杂骨形态发生蛋白-2时,才能实现两个参数的明显增加。然而,在兔颅骨的临界尺寸缺陷中,钛支架的表现明显优于基于TCP的支架,这很可能是由于其较高的机械稳定性。

综上所述,我们认为,相同微结构的钛和基于TCP的支架在骨再生方面表现同样好,只要微结构满足植入部位的机械需求即可。

原始出处:

Tse-Hsiang Chen, Chafik Ghayor, et al., Lattice Microarchitecture for Bone Tissue Engineering from Calcium Phosphate Compared to Titanium. Tissue Eng Part A. 2018 Oct 1; 24(19-20): 1554–1561.

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    2019-01-16 30397613
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    2019-05-27 xuyu
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    2019-02-01 spoonycyy
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    2018-11-03 zhaojie88
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