Am J Rhinol Allergy:利用鼻腔细胞学和免疫球蛋白E抗体水平对过敏性鼻炎症候的评估

2018-01-27 AlexYang MedSci原创

在婴幼儿中鉴定过敏性鼻炎的症候是困难的,因为做出一个总结性的诊断具有挑战。研究人员利用鼻拭子中细胞的差异和对食物和吸入性过敏原的免疫球蛋白E(slgE)抗体水平值来进行诊断,并且鉴定了相关的过敏原来对过敏性鼻炎的症候进行了调查。研究包括了302名儿童,年龄在2到120个月,并且他们都因流鼻涕而在他们的诊所治疗。研究发现,参与者在2-14个月(n=84)、15-24个月(n=57)、 25-60 个

在婴幼儿中鉴定过敏性鼻炎的症候是困难的,因为做出一个总结性的诊断具有挑战。研究人员利用鼻拭子中细胞的差异和对食物和吸入性过敏原的免疫球蛋白E(slgE)抗体水平值来进行诊断,并且鉴定了相关的过敏原来对过敏性鼻炎的症候进行了调查。

研究包括了302名儿童,年龄在2到120个月,并且他们都因流鼻涕而在他们的诊所治疗。研究发现,参与者在2-14个月(n=84)、15-24个月(n=57)、 25-60 个月(n = 73)和61-120个月(n=88)不同年龄段中,具有Eo-Mc和Eo-Mc-N (Eo:嗜酸细胞,Mc:肥大细胞,N:中性粒细胞)的比例分别为20、23、 58和 65%。在 2-14个月和15-24个月年龄组之间、 25-60和 61-120 个月年龄组之间没有显著的差异,但是在 15-24个月和25-60个月年龄组之间存在着显著的差异(p=0.00013)。另外,参与者具有对食物和吸入性过敏原slgE抗体的比例分别:在2-14个月为12%/0%, 在15-24个月为10.5%/7%, 在25-60 个月为1.3%/42.4% 以及在61-120个月为0%/56.8%,并且在15-24个月组和25-60个月组之间具有显著的差异(p=0.00025)。

最后,研究人员指出,在小于15个月的婴儿中,过敏性鼻炎与吸入性过敏原相关的时间是少有的,但是在这些婴儿中,鼻炎的症状也许与对食物过敏原的slgE相关。从对食物到吸入性过敏原slgE响应的交替发生在15个月大的儿童中,并且在25个月大以后,slgE对吸入性过敏原的抗体尤为显著。

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    2018-08-07 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

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    2018-08-19 xzw113
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    2018-05-26 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

  4. 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encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Thu Dec 06 21:55:00 CST 2018, time=2018-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805014, encodeId=edba1805014e2, content=<a href='/topic/show?id=48c5e788217' target=_blank style='color:#2F92EE;'>#细胞学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77882, encryptionId=48c5e788217, topicName=细胞学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4723380, createdName=yangcx0915, createdTime=Mon Jan 29 07:55:00 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283889, encodeId=fe911283889a0, content=<a href='/topic/show?id=ce1b2908938' target=_blank style='color:#2F92EE;'>#免疫球蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29089, encryptionId=ce1b2908938, topicName=免疫球蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=560d188, createdName=nymo, createdTime=Mon Jan 29 13:55:00 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329075, encodeId=afcd13290e5d3, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Jan 29 13:55:00 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465828, encodeId=55b6146582810, content=<a href='/topic/show?id=736b103508c6' target=_blank style='color:#2F92EE;'>#鼻腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103508, encryptionId=736b103508c6, topicName=鼻腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=224e6763385, createdName=mnda, createdTime=Mon Jan 29 13:55:00 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283056, encodeId=6213283056de, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon Jan 29 04:56:52 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282794, encodeId=8357282e94ca, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sun Jan 28 07:40:37 CST 2018, time=2018-01-28, status=1, ipAttribution=)]
    2018-01-29 膀胱癌
  8. [GetPortalCommentsPageByObjectIdResponse(id=337145, encodeId=bb4c33e145b4, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue Aug 07 17:57:19 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035160, encodeId=3f172035160f6, content=<a href='/topic/show?id=5a426866eae' target=_blank style='color:#2F92EE;'>#球蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68667, encryptionId=5a426866eae, topicName=球蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2317301, 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encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Thu Dec 06 21:55:00 CST 2018, time=2018-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805014, encodeId=edba1805014e2, content=<a href='/topic/show?id=48c5e788217' target=_blank style='color:#2F92EE;'>#细胞学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77882, encryptionId=48c5e788217, topicName=细胞学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4723380, createdName=yangcx0915, createdTime=Mon Jan 29 07:55:00 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283889, encodeId=fe911283889a0, content=<a href='/topic/show?id=ce1b2908938' target=_blank style='color:#2F92EE;'>#免疫球蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29089, encryptionId=ce1b2908938, topicName=免疫球蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=560d188, createdName=nymo, createdTime=Mon Jan 29 13:55:00 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329075, encodeId=afcd13290e5d3, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Jan 29 13:55:00 CST 2018, time=2018-01-29, status=1, ipAttribution=), 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createdName=三生有幸9135, createdTime=Mon Jan 29 04:56:52 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282794, encodeId=8357282e94ca, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sun Jan 28 07:40:37 CST 2018, time=2018-01-28, status=1, ipAttribution=)]
    2018-01-29 mnda
  9. 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encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Thu Dec 06 21:55:00 CST 2018, time=2018-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805014, encodeId=edba1805014e2, content=<a href='/topic/show?id=48c5e788217' target=_blank style='color:#2F92EE;'>#细胞学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77882, encryptionId=48c5e788217, topicName=细胞学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4723380, createdName=yangcx0915, createdTime=Mon Jan 29 07:55:00 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283889, encodeId=fe911283889a0, content=<a href='/topic/show?id=ce1b2908938' target=_blank style='color:#2F92EE;'>#免疫球蛋白#</a>, beContent=null, objectType=article, 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createdName=三生有幸9135, createdTime=Mon Jan 29 04:56:52 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282794, encodeId=8357282e94ca, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sun Jan 28 07:40:37 CST 2018, time=2018-01-28, status=1, ipAttribution=)]
    2018-01-29 三生有幸9135

    学习一下谢谢分享

    0

  10. 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    2018-01-28 yjs木玉

    好好好好好好好好

    0

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