Lancet infect dis:HIV合并HCV感染的负担(全球性meta分析)

2016-02-27 MedSci MedSci原创

原始出处:Lucy Platt,Philippa Easterbrook,et al, Prevalence and burden of HCV co-infection in people living with HIV: a global systematic review and meta-analysis,lancet infect disease,24 February 2016http

背景:全球有3700万人群感染HIV,1亿1千5百万人有HCV抗体。对于HIV合并HCV感染知之甚少。我们试图发现HIV病人中合并HCV感染的患病率和疾病负担。

方法:我们搜索了MEDLINE, Embase, CINAHL+, POPLINE, Africa-wide Information, Global Health, Web of Science, and the Cochrane Library
和WHO数据库中2002年1月1日-2015年1月28日关于HCV和HIV感染发病率的研究。包括样本量超过50个HIV感染者的研究,招募HIV感染阶段或有其他行为特征的患者。排除社评,HCV或HIV-HCV联合感染病例,或基于自我报道感染的病例。同时排除有合并症或正在接受干预治疗有发生联合感染风险的人群。根据HVI暴露及已报道的HIV感染评估联合感染的地区疾病负担进行分类。我们使用meta分析来评估HIV感染者发生HCV感染与HIV阴性患者的发病风险。

发现:在31767篇引用文献中,有783个符合要求,902个关于HIV-HCV感染患病率的估计。一般人群中,HIV感染者发生HIV-HCV联合感染为2.4% (IQR 0.8–5.8),孕妇或异性恋为4.0% (1.2–8.4),男男性交(MSM)人群为 6.4% (3.2–10.0),注射毒品(PWID)人群为82.4% (55.2–88.5)。HIV感染者发生HCV感染的概率是HIV阴性人群的6倍 (5.8, 95% CI 4.5–7.4)。世界范围内,大约有2278400例(IQR 1271300—4417000)HIV-HCV混合感染病例,有大约1362700 (847700–1381800)发生在PWID人群中,相当于整个HIV感染人群发生混合感染的6.2%(3.4–11.9)。

说明:我们发现HIV阳性人群发生HCV感染的概率在所有地区和高风险人群中均较HIV阴性者高,尤其是PWID人群中。这项研究高度提示了对所有HIV感染者进行HCV检测的重要性,尤其是PWID人群。仍需要加强国家范围内对所有地区不同人群HCV感染的监管。

原始出处:

Lucy Platt,Philippa Easterbrook,et al, Prevalence and burden of HCV co-infection in people living with HIV: a global systematic review and meta-analysis,lancet infect disease,24 February 2016

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    2016-05-09 howi
  3. 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    2016-06-22 一闲
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topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed Apr 06 12:12:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66757, encodeId=548466e57ca, content=大神啊,工作量之大,怎么也要百来人吧!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4d631686395, createdName=1de48cf7m45(暂无匿称), createdTime=Wed Mar 02 10:40:00 CST 2016, time=2016-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66648, encodeId=ce2f66648ed, content=反复习吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Mar 01 18:20:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66564, encodeId=b5046656416, content=吊了, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160301/IMG56D53216887587291.jpg, createdBy=3c131694128, createdName=破风4392, createdTime=Tue Mar 01 15:06:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66544, encodeId=07dd665447c, content=求原文, beContent=null, objectType=article, channel=null, level=null, likeNumber=182, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuHfSLw3PzIKiaSnTBUuAtRkrrxWpibukl35iciaGtBq4LYQv4ian1tPC3IdmzWI2dZ3cDC8wUg5CnBxlJ/0, createdBy=33a51675735, createdName=jiangxianchen, createdTime=Tue Mar 01 14:59:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257622, encodeId=5284125e62220, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Feb 29 11:12:00 CST 2016, time=2016-02-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618963, encodeId=7d3916189636d, content=<a href='/topic/show?id=5f1785e9d5' target=_blank style='color:#2F92EE;'>#HCV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8579, encryptionId=5f1785e9d5, topicName=HCV感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb419968800, createdName=12498e5fm18(暂无昵称), createdTime=Mon Feb 29 11:12:00 CST 2016, time=2016-02-29, status=1, ipAttribution=)]
    2016-04-06 guojianrong
  5. 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createdTime=Tue Mar 01 14:59:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257622, encodeId=5284125e62220, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Feb 29 11:12:00 CST 2016, time=2016-02-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618963, encodeId=7d3916189636d, content=<a href='/topic/show?id=5f1785e9d5' target=_blank style='color:#2F92EE;'>#HCV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8579, encryptionId=5f1785e9d5, topicName=HCV感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb419968800, createdName=12498e5fm18(暂无昵称), createdTime=Mon Feb 29 11:12:00 CST 2016, time=2016-02-29, status=1, ipAttribution=)]
    2016-03-02 1de48cf7m45(暂无匿称)

    大神啊,工作量之大,怎么也要百来人吧!

    0

  6. 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2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66564, encodeId=b5046656416, content=吊了, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160301/IMG56D53216887587291.jpg, createdBy=3c131694128, createdName=破风4392, createdTime=Tue Mar 01 15:06:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66544, encodeId=07dd665447c, content=求原文, beContent=null, objectType=article, channel=null, level=null, likeNumber=182, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuHfSLw3PzIKiaSnTBUuAtRkrrxWpibukl35iciaGtBq4LYQv4ian1tPC3IdmzWI2dZ3cDC8wUg5CnBxlJ/0, createdBy=33a51675735, createdName=jiangxianchen, createdTime=Tue Mar 01 14:59:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257622, encodeId=5284125e62220, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Feb 29 11:12:00 CST 2016, time=2016-02-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618963, encodeId=7d3916189636d, content=<a href='/topic/show?id=5f1785e9d5' target=_blank style='color:#2F92EE;'>#HCV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8579, encryptionId=5f1785e9d5, topicName=HCV感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb419968800, createdName=12498e5fm18(暂无昵称), createdTime=Mon Feb 29 11:12:00 CST 2016, time=2016-02-29, status=1, ipAttribution=)]
    2016-03-01 忠诚向上

    反复习吧

    0

  7. 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topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed Apr 06 12:12:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66757, encodeId=548466e57ca, content=大神啊,工作量之大,怎么也要百来人吧!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4d631686395, createdName=1de48cf7m45(暂无匿称), createdTime=Wed Mar 02 10:40:00 CST 2016, time=2016-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66648, encodeId=ce2f66648ed, content=反复习吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Mar 01 18:20:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66564, encodeId=b5046656416, content=吊了, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160301/IMG56D53216887587291.jpg, createdBy=3c131694128, createdName=破风4392, createdTime=Tue Mar 01 15:06:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66544, encodeId=07dd665447c, content=求原文, beContent=null, objectType=article, channel=null, level=null, likeNumber=182, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuHfSLw3PzIKiaSnTBUuAtRkrrxWpibukl35iciaGtBq4LYQv4ian1tPC3IdmzWI2dZ3cDC8wUg5CnBxlJ/0, createdBy=33a51675735, createdName=jiangxianchen, createdTime=Tue Mar 01 14:59:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257622, encodeId=5284125e62220, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Feb 29 11:12:00 CST 2016, time=2016-02-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618963, encodeId=7d3916189636d, content=<a href='/topic/show?id=5f1785e9d5' target=_blank style='color:#2F92EE;'>#HCV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8579, encryptionId=5f1785e9d5, topicName=HCV感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb419968800, createdName=12498e5fm18(暂无昵称), createdTime=Mon Feb 29 11:12:00 CST 2016, time=2016-02-29, status=1, ipAttribution=)]
    2016-03-01 破风4392

    吊了

    0

  8. 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2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66564, encodeId=b5046656416, content=吊了, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160301/IMG56D53216887587291.jpg, createdBy=3c131694128, createdName=破风4392, createdTime=Tue Mar 01 15:06:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66544, encodeId=07dd665447c, content=求原文, beContent=null, objectType=article, channel=null, level=null, likeNumber=182, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuHfSLw3PzIKiaSnTBUuAtRkrrxWpibukl35iciaGtBq4LYQv4ian1tPC3IdmzWI2dZ3cDC8wUg5CnBxlJ/0, createdBy=33a51675735, createdName=jiangxianchen, createdTime=Tue Mar 01 14:59:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257622, encodeId=5284125e62220, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Feb 29 11:12:00 CST 2016, time=2016-02-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618963, encodeId=7d3916189636d, content=<a href='/topic/show?id=5f1785e9d5' target=_blank style='color:#2F92EE;'>#HCV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8579, encryptionId=5f1785e9d5, topicName=HCV感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb419968800, createdName=12498e5fm18(暂无昵称), createdTime=Mon Feb 29 11:12:00 CST 2016, time=2016-02-29, status=1, ipAttribution=)]
    2016-03-01 jiangxianchen

    求原文

    0

  9. 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createdTime=Tue Mar 01 14:59:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257622, encodeId=5284125e62220, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Feb 29 11:12:00 CST 2016, time=2016-02-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618963, encodeId=7d3916189636d, content=<a href='/topic/show?id=5f1785e9d5' target=_blank style='color:#2F92EE;'>#HCV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8579, encryptionId=5f1785e9d5, topicName=HCV感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb419968800, createdName=12498e5fm18(暂无昵称), createdTime=Mon Feb 29 11:12:00 CST 2016, time=2016-02-29, status=1, ipAttribution=)]
    2016-02-29 爆笑小医
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