Stroke: 美国社区老人颅内动脉粥样硬化狭窄的发生率

2016-04-10 MedSci MedSci原创

背景:颅内动脉粥样硬化性狭窄(ICAS)是脑卒中的常见原因,但是对其流行病学的了解较少。研究者在美国心血管队列中,应用高分辨率磁共振血管造影研究ICAS与血管危险因素的相关性。方法:社区动脉粥样硬化风险研究(ARIC)在1987到1989年间从4个美国社区招募受试者。采用分层抽样的方法,研究者从visit5选出1980名受试者进行高分辨率3T磁共振血管造影。所有的图像在一个中心实验室分析,ICAS

背景:颅内动脉粥样硬化性狭窄(ICAS)是脑卒中的常见原因,但是对其流行病学的了解较少。研究者在美国心血管队列中,应用高分辨率磁共振血管造影研究ICAS与血管危险因素的相关性。

方法:社区动脉粥样硬化风险研究(ARIC)在1987到1989年间从4个美国社区招募受试者。采用分层抽样的方法,研究者从visit5选出1980名受试者进行高分辨率3T磁共振血管造影。所有的图像在一个中心实验室分析,ICAS分级为:无狭窄,<50%狭窄,50%至69%狭窄,70%至99%的狭窄和完全闭塞。研究者计算ICAS每血管,每人的发生率(对visit5受试者6538人进行加权),并评估美国人群ICAS的发生率。研究者应用多变量logistic回归ICAS相关的独立变量。

结果:有磁共振血管造影的受试者共1765例,年龄在67岁至90岁,男性41%,70%是白人,29%是黑人。31%的受试者存在ICAS,并且9%的受试者ICAS≥50%。ICAS≥50%的65岁到90岁的美国白人的发生率为8%,黑人的发生率为12%。高龄,黑人,收缩压较高,低密度脂蛋白较高与ICAS发生风险增加相关,然而,高密度脂蛋白水平较高及使用降胆固醇药物与ICAS降低相关。BMI与ICAS不相关。

结论:老年人ICAS的患病率高,并肯能是老年人的卒中和痴呆一级预防的目标。

原文出处:

Suri MF, Qiao Y, et al. Prevalence of Intracranial Atherosclerotic Stenosis Using High-Resolution Magnetic Resonance Angiography in the General Population: The Atherosclerosis Risk in Communities Study. Stroke. 2016 Apr 7.

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    2016-09-18 ylzr123

    点个赞!好文章有待学习探讨。

    0

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    2016-04-14 李继凯

    值得学习

    0

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    2016-04-14 李继凯

    文章不错

    0

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    2016-04-11 hekzn

    学习了 长知识

    0