SCI REP:主动脉瓣置换术对重度主动脉瓣狭窄和正常收缩功能的影响!

2017-07-12 xing.T MedSci原创

由此可见,AVR对不同严重程度的AS患者赋予不同的生存益处:它是在NFHG患者中最为有效(进行AVR的RR/没有AVR的RR为0.43;95%可信区间为0.22-0.82),在LFLG患者中最差(进行AVR的RR/没有AVR的RR为1.19;95%可信区间为0.74-1.94)。

不同血流梯度状态下的严重主动脉瓣狭窄(AS)患者接受主动脉瓣置换术(AVR)的生存获益尚不清楚。

近日,Scientific reports 杂志上发表了一篇荟萃分析文章,研究人员对PubMed、MEDLINE、EMBASE、Cochrane图书馆、CNKI和OpenGrey等数据库进行了全面的检索,并确定了调查严重AS预后(有效瓣口面积≤1cm2)和左室射血分数≥50%的研究。严重AS是根据平均压力梯度 [阈值为40mmHg;高梯度(HG)和低梯度(LG)]和每搏指数[阈值为35ml/m2;正常流量(NL)和低流量(LF)] 来进行分层。研究人员进行了网络荟萃分析,以评估各子型AS患者的全因死亡率,通过报告率比(RR)。研究人员采用网络Meta回归分析了AVR对预后的影响。

在汇总分析(15项研究,9737例患者)中,LF状态(HG和LG)与死亡率增加相关(LFLG:RR为1.88;95%可信区间为1.43-2.46;LFHG:RR为1.77;95%可信区间为1.16-2.70),相比于中度AS患者;在NF状态在HG和LG患者中也有类似的预后(NFLG:RR为1.11;95%可信区间为0.81-1.53;NFHG:RR为1.16;95%可信区间为0.82-1.64)。

由此可见,AVR对不同严重程度的AS患者赋予不同的生存益处:它是在NFHG患者中最为有效(进行AVR的RR/没有AVR的RR为0.43;95%可信区间为0.22-0.82),在LFLG患者中最差(进行AVR的RR/没有AVR的RR为1.19;95%可信区间为0.74-1.94)。

原始出处:

Qishi Zheng,et al. Effects of Aortic Valve Replacement on Severe Aortic Stenosis and Preserved Systolic Function: Systematic Review and Network Meta-analysis.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-05021-9

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    2018-04-19 yxch48
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    2017-07-13 zwjnj2

    好不好好学习感谢梅斯

    0

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