肝细胞癌根治术对肿瘤血管内皮细胞生成因子有良好的抑制作用

2012-04-27 小哲 摘编 医学论坛网

  近日,解放军总医院肝胆外科夏红天、郭广宏、黄晓强等人共同发表论文,旨在探讨与手术切除比较,明确肝细胞癌肝动脉栓塞化疗(TACE)前、后血管内皮细胞生长相关细胞因子含量变化。研究指出,TACE治疗后患者血清促进血管内皮细胞生长的细胞因子含量明显高于手术切除组;而抑制血管内皮细胞生长的细胞因子含量明显低于手术切除组。肝细胞癌根治性手术切除对肿瘤血管内皮细胞生成因子的抑制作用明显好于TACE治疗的抑

  近日,解放军总医院肝胆外科夏红天、郭广宏、黄晓强等人共同发表论文,旨在探讨与手术切除比较,明确肝细胞癌肝动脉栓塞化疗(TACE)前、后血管内皮细胞生长相关细胞因子含量变化。研究指出,TACE治疗后患者血清促进血管内皮细胞生长的细胞因子含量明显高于手术切除组;而抑制血管内皮细胞生长的细胞因子含量明显低于手术切除组。肝细胞癌根治性手术切除对肿瘤血管内皮细胞生成因子的抑制作用明显好于TACE治疗的抑制作用。该文发表在2012 年第18卷第1期《中华肝胆外科杂志》上。

  手术切除组30例,TACE组30例。利用生物蛋白芯片技术检测血清中多种细胞因子的含量。

  结果治疗前两组患者血管内皮相关细胞因子含量无显著差异。治疗后两组患者血清促血管内皮细胞生长因子显著下降,抑制血管内皮细胞生长因子显著升高。肝细胞癌患者行TACE治疗后血清中细胞因子IL-6、IL-8、VEGF和EGF的含量明显高于手术切除组;而细胞因子IL-10、IFNγ和TNFα的含量明显低于手术切除组。
    

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    2012-07-08 xjy02
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    2012-04-29 jeanqiuqiu