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Mov Disord.:7T磁共振发现REM期睡眠行为障碍患者脑干核间结构连接受损

2022-01-07 影像小生 MedSci原创

脑干REM期睡眠行为障碍
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该研究的发现的人类iRBD的脑干核连接受损图扩展了动物模型，是研究和评估前驱共核病分期的一个有前途的工具。

快速眼动(REM)睡眠行为障碍(iRBD)是α共核蛋白病的早期表现之一。在动物模型中已经描述了REM睡眠行为障碍的脑干病理生理学基础，但由于缺乏在体脑干核图谱和有限的磁共振成像(MRI)敏感性，在人身上的研究还不够。

María G. García-Gomar等利用活体概率脑干核团图谱和7TMRI研究iRBD患者脑干结构连接的变化。

该研究对12例iRBD患者和12例对照患者的结构连接进行概率示示。采用双侧Wilcoxon秩和检验比较各组间的结构连接指标。

iRBD中脑干14个核核的结构连接受损(Z = 2.6, P<0.01)，包括REM-on区和REM睡眠肌张力减退区之间的连接。

目前对iRBD生理病理知识的理解主要来自动物研究，因为有几个因素阻碍了对人活体这种睡眠障碍的研究，主要是缺乏一个图集来精确定位活体的小脑干结构，以及扩散MRI的灵敏度/分辨率有限。该研究结果克服了这两个限制，通过将原始脑干核图映射到活体的高空间分辨率HARDI(7T)。

该研究的发现的人类iRBD的脑干核连接受损图扩展了动物模型，是研究和评估前驱共核病分期的一个有前途的工具。

原文出处

García-Gomar MG, Videnovic A, Singh K, et al. Disruption of Brainstem Structural Connectivity in REM Sleep Behavior Disorder Using 7 Tesla Magnetic Resonance Imaging [published online ahead of print, 2021 Dec 29]. Mov Disord. 2021;10.1002/mds.28895. doi:10.1002/mds.28895

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    2022-09-02 tongyongming

    #REM#

    0

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    2022-05-01 cmsvly

    #Disord#

    0

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    2022-12-19 12498cb5m23暂无昵称

    #行为障碍#

    0

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    2022-07-20 cmj8wellington

    #Dis#

    0

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    2022-01-06 1696533704_45270454

    #磁共振#

    0

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