J Nanobiotechnology:新型纳米材料可抑制金黄色葡萄球菌和铜绿假单胞菌的生长

2017-08-10 MedSci MedSci原创

纳米技术正不断地改变我们周围的世界,其广泛应用(包括环境保护等)提高了我们的生活质量,其中大众比较关注的是生物变质问题。在这项研究中,研究人员制备了一种由石墨烯纳米片并以氧化锌纳米棒修饰(ZNGs)的新型材料,以探究其抑制革兰氏阳性金黄色葡萄球菌和革兰氏阴性铜绿假单胞菌的作用。这两种病原体常与医院感染及生物变质现象相关。时间及剂量依赖性杀菌效果较为突出,表明ZNGs具有很强的抗菌潜力。此外,场发射

纳米技术正不断地改变我们周围的世界,其广泛应用(包括环境保护等)提高了我们的生活质量,其中大众比较关注的是生物变质问题。

在这项研究中,研究人员制备了一种由石墨烯纳米片并以氧化锌纳米棒修饰(ZNGs)的新型材料,以探究其抑制革兰氏阳性金黄色葡萄球菌和革兰氏阴性铜绿假单胞菌的作用。这两种病原体常与医院感染及生物变质现象相关。

时间及剂量依赖性杀菌效果较为突出,表明ZNGs具有很强的抗菌潜力。此外,场发射扫描电子显微镜(SEM)分析细菌表面,发现在细胞壁水平ZNGs可发挥机械作用。由于这种纳米材料的纳米针样的作用及其纳米刀效应,ZNGs可诱导这些细菌深层物理损伤。经傅里叶变换红外光谱证实细胞损伤,揭示ZNGs的抗菌作用与蛋白和磷脂的变化以及在胞外聚合物的降低有关;同时ZNGs还可减少两种细菌生物膜的形成。建筑材料中ZNGs抗菌性能的特点使得其成为室内/室外表面保护的一种工具。最后,使用秀丽隐杆线虫评估ZNGs的纳米毒性。值得注意的是,ZNGs对秀丽隐杆线虫的幼体发育、寿命、生育以及神经肌肉功能均无有害作用。

总的来说,ZNGs的生物相容性较好,可用于抗菌药物的研发。

原始出处:


Elena Zanni, Erika Bruni, et al., Evaluation of the antibacterial power and biocompatibility of zinc oxide nanorods decorated graphene nanoplatelets: new perspectives for antibiodeteriorative approaches. J Nanobiotechnology. 2017; 15: 57. Published online 2017 Aug 1. doi: 10.1186/s12951-017-0291-4.

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    2018-06-01 shock_melon
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    2018-02-27 sunylz
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    2017-08-10 虈亣靌

    体外与体内还有很长时间的路要走,希望顺利吧

    0

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