有睡眠呼吸暂停?河北人民医院研究称,用呼吸机可改善左室功能

2019-02-19 岱西 中国循环杂志

阻塞性睡眠呼吸暂停综合征(OSAS)这种呼吸系统障碍性疾病,是高血压、冠心病、糖尿病等的高危因素。那么无创持续气道正压通气治疗OSAS后,心脏会有哪些改变?

阻塞性睡眠呼吸暂停综合征(OSAS)这种呼吸系统障碍性疾病,是高血压、冠心病、糖尿病等的高危因素。那么无创持续气道正压通气治疗OSAS后,心脏会有哪些改变?

河北省人民医院高洁等进行的研究表明,无创持续气道正压通气治疗不仅可以减轻OSAS的严重程度,也可以改善患者左心室功能。

研究显示,无创持续气道正压通气治疗期间和治疗后6~8个月,OSAS患者的左心室射血分数增加,左心室舒张早期快速充盈的充盈峰与二尖瓣环运动峰值速度比值(E/Ea)显着降低(P均<0.05)。

左心室多普勒心肌组织成像则显示,治疗期间和治疗后 6~8 个月室间隔基底段 E 峰速度、舒张晚期充盈的充盈峰速度、基底段侧壁 E 峰速度和三尖瓣血流 E波速度显着改善(P均 <0.05)。

左心室侧壁(基底段、中间段和心尖段)、室间隔(基底部、中部和心尖部)和整体心肌应变显着改善(P均 <0.05)。

而且,治疗期间睡眠呼吸暂停低通气指数(AHI)也较治疗前显着改善(P<0.001)。

研究还表明,无创持续气道正压通气治疗利于 OSAS患者的左心室心肌指数恢复,在治疗期间 OSAS 患者的左心室心肌整体纵向应变能力和局部 2D 应变峰值显着增加,表明无创通气能够促进左心室心肌形变的改善。

此外,该研究还有两个发现,一是OSAS患者偏胖;而是OSAS患者早期出现左心室和右心室功能紊乱,其功能的异常与通气前OSAS严重程度和血乳酸浓度密切相关。

这提示,肥胖OSAS患者并伴有肺泡换气不足或睡眠时严重呼吸暂停均可增加临床症状表现不明显的左右心室心肌功能紊乱而增加致病的风险。

这项研究共纳入85例OSAS 患者和35例健康受试者。

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    2019-02-20 Boyinsh
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    2019-02-20 全主任

    mark

    0

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    2019-02-19 zwjnj2

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