JACC:孕期自发性冠脉夹层的临床研究

2017-07-19 MedSci MedSci原创

自发性冠状动脉夹层是最常见的孕期导致心肌梗塞的原因,发病机制尚未阐明。近日,在国际心血管权威杂志JACC上发表了一篇旨在评估孕期自发性冠脉夹层(P-SCAD)和非孕期自发性冠脉夹层(NP-SCAD)的临床表现、危险因素和预后结局相关性的临床研究。 梅奥诊所在2010年建立了一个SCAD的数据库,本研究从该数据库中回顾分析了孕期伴有自发性冠脉夹层和产后≤12周伴有自发性冠脉夹层的孕妇,最终纳入

自发性冠状动脉夹层是最常见的孕期导致心肌梗塞的原因,发病机制尚未阐明。近日,在国际心血管权威杂志JACC上发表了一篇旨在评估孕期自发性冠脉夹层(P-SCAD)和非孕期自发性冠脉夹层(NP-SCAD)的临床表现、危险因素和预后结局相关性的临床研究。

梅奥诊所在2010年建立了一个SCAD的数据库,本研究从该数据库中回顾分析了孕期伴有自发性冠脉夹层和产后≤12周伴有自发性冠脉夹层的孕妇,最终纳入了323例孕妇,54例孕妇符合P-SCAD的入选标准,269例孕妇归入NP-SCAD组。

研究结果显示,与NP-SCAD组孕妇相比,P-SCAD孕妇ST抬高型心肌梗塞的发生率更高(57% vs 36%; p = 0.009),左主干和分支冠脉SCAD的发生率也更高(24% vs 5%; p < 0.0001;33% vs 14%; p = 0.0027)。P-SCAD孕妇的纤维肌发育不良和冠状动脉外血管异常发生率更低((42% vs 64%; p = 0.047; 46% vs 77%; p = 0.0032)。此外,与美国出生数据相比较后发现,P-SCAD孕妇的多胎率更高(p = 0.0167),不孕不育发生率和先兆子痫发病率更高(p=0.0004;p=0.001

研究结果显示,P-SCAD患者比NP-SCAD患者具有更多的急性发作和高危临床特征。P-SCAD发生率最高的是产后第一个月内,并且P-SCAD患者经常出现脑血管异常。

原始出处:

Marysia S et al.Spontaneous Coronary Artery Dissection Associated With Pregnancy.JACC.2017 July.

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    2017-12-27 hbwxf
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    2017-07-29 lou.minghong

    学习了谢谢分享!

    0

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    2017-07-21 sodoo
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    2017-07-20 Chongyang Zhang

    签到学习了很多人

    0

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    2017-07-19 三生有幸9135

    学习一下谢谢分享

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