Neurology:面孔失认可提示抗NMDA受体脑炎

2018-06-23 zyx整理 神经科病例撷英拾粹

23岁右利手女性,表现为进行性面部识别困难3周,包括其自己的面孔,随后出现精神异常。

23岁右利手女性,表现为进行性面部识别困难3周,包括其自己的面孔,随后出现精神异常。头颅CT平扫和增强MRI提示右后部颞叶和梭状回无强化病灶,对应的头部FDG-PET/CT上为高代谢(图)。脑电图证实右后侧颞区慢波。脑脊液和血清抗NMDA受体(NMDAR)抗体阳性,腹部/盆腔CT可见卵巢畸胎瘤。 切除畸胎瘤,血浆置换和1个周期的利妥昔单抗治疗后症状缓解超过1月。抗NMDAR脑炎罕见表现为面部失认,本例患者症状可能继发于右侧梭状回功能障碍。


(图:A:CT头显示右后颞部低密度;B-C:FLAIR可见右后颞叶和梭状回高信号;D-E:FDG-PET/CT图像证实右后侧颞区高代谢)

原始出处:

Beecher G, Wagner AN, Abele J, Smyth P. Teaching NeuroImages: Prosopagnosia heralding anti-NMDA receptor encephalitis. Neurology. 2018 May 29;90(22):e2012-e2013.

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    2019-02-21 yinhl1978
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    2018-11-25 wetgdt
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    2018-06-24 飘飘爱

    很好

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2000477, encodeId=0c7120004e776, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Feb 21 14:11:00 CST 2019, time=2019-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2030215, encodeId=90c020302158a, content=<a href='/topic/show?id=4a67128814c' target=_blank style='color:#2F92EE;'>#NMDA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12881, encryptionId=4a67128814c, topicName=NMDA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=838d2500169, createdName=12498cb5m13暂无昵称, createdTime=Mon Dec 17 10:11:00 CST 2018, time=2018-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943549, encodeId=f73f194354998, content=<a href='/topic/show?id=daad11404a3' target=_blank style='color:#2F92EE;'>#MDA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11404, encryptionId=daad11404a3, topicName=MDA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Sun Nov 25 20:11:00 CST 2018, time=2018-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343579, encodeId=4c6213435e938, content=<a href='/topic/show?id=928a849314c' target=_blank style='color:#2F92EE;'>#脑炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84931, encryptionId=928a849314c, topicName=脑炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/22AEC2EC4805C29C6E1DEE6D888DB41C/100, createdBy=7a322500193, createdName=ms1779634646866130, createdTime=Mon Jun 25 03:11:00 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326680, encodeId=0a8e326680e7, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2emBzjO0FtqTJ05AqrEEdRmp6tmlsLXqpzfxWdtgbbgPGWRHagoK9fLTd3IayRPgkJVIVBWtdlmnkBhOIR4cFM/0, createdBy=e8d51649330, createdName=飘飘爱, createdTime=Sun Jun 24 19:00:29 CST 2018, time=2018-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326343, encodeId=202432634346, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Jun 23 12:47:35 CST 2018, time=2018-06-23, status=1, ipAttribution=)]
    2018-06-23 sunfeifeiyang

    0