J Gastroen Hepatol:细化结家族结肠癌史对风险人群的影响

2018-03-04 zhangfan MedSci原创

研究认为,家族结肠癌史并非一个笼统的概念,不同年龄段、数量以及亲属类型对结肠风险的影响具有显著性差异

结直肠癌家族史是结直肠癌的一个重要危险因素,但需要更详细的数据来制定有效的筛查指南。近日研究人员依据亲属关系(一级、二级亲属或堂兄弟姐妹)、数量以及年龄(30-39,40-49或≥50 岁)评估风险人员的结直肠肿瘤风险(CRN)。

研究人员对98562名30岁以上接受结肠镜检查的无症状人群数据进行考察,得出相应研究结论。

参与者平均年龄41.4岁,CRN率为15.7%。参与者中,1或2名1级亲属患结肠癌的参与者,其结肠癌风险较无结肠癌家族史人群显著升高,但2级亲属以及堂兄弟姐妹不受风险增加的影响。在30-39和40-49岁年龄组中,家族史增加除堂兄弟姐妹外亲属人群的CRN和晚期CRN风险,但对于50岁以上有家族结肠癌史的人群,堂兄弟姐妹人群的晚期结肠癌风险高于一级亲属(父亲风险为0.39;母校为0.43)。

研究认为,家族结肠癌史并非一个笼统的概念,不同年龄段、数量以及亲属类型对结肠风险的影响具有显著性差异。

原始出处:


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    2018-03-08 许安
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    2018-03-07 虈亣靌

    不错!好好学习一下

    0

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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Sun Mar 04 08:42:17 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292849, encodeId=5eb029284924, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sun Mar 04 08:28:35 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292835, encodeId=163129283501, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Mar 04 08:21:12 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-03-06 雅文博武

    学习了很多先进的医学知识

    0

  5. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Sun Mar 04 08:42:17 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292849, encodeId=5eb029284924, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sun Mar 04 08:28:35 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292835, encodeId=163129283501, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Mar 04 08:21:12 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-03-06 秀红

    学习了

    0

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channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Mar 04 08:21:12 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-03-05 gwc384
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channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Mar 04 08:21:12 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-03-04 明月清辉

    谢谢分享.学习了

    0

  8. 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channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Mar 04 08:21:12 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-03-04 chunjianf

    学习了.谢谢分享

    0

  9. 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channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Mar 04 08:21:12 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-03-04 yjs木玉

    好好好好好好好好

    0

  10. 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channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Mar 04 08:21:12 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-03-04 1ddf0692m34(暂无匿称)

    学习了.谢谢分享

    0

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据国家癌症中心最新发布的《2017中国肿瘤现状和趋势》,结、直肠癌发病率在中国男性患者中位居第五,在女性患者中则进入前三名。以总体肠癌发病人数而言,中国患者人数已跃居世界第一位。90%的恶性结肠肿瘤均由结肠息肉发展而来,其中腺瘤性息肉的恶变几率远远超过普通炎性息肉。临床研究表明结肠癌发病常常表现出家族性,且60%患者体内存在腺瘤性息肉易感蛋白(Adenomatous Polyposis Coli,APC )编码基因突变,该突变在癌细胞转移过程中扮演了重要角色。

Gut:肠道微生物在免疫细胞杀灭结直肠肿瘤过程中发挥重要作用

研究认为肠道菌群可刺激产生免疫趋化因子,有利于T细胞杀灭肿瘤

Brit J Cancer:多种结肠癌风险筛查模型效果外部验证研究

研究证实,在英国队列中,7种结肠癌风险模型表现出较好的疾病预测效果,上述模型有望成为结肠癌潜在风险筛查中最具健康效益和成本效益的方法

JCO:食用坚果有利于Ⅲ期结肠癌患者生存

既往的观察性研究报道高胰岛素血症患者的结肠癌复发率和死亡率增高,包括Ⅱ型糖尿病,肥胖,久坐生活方式和高糖负荷饮食等。食用坚果与Ⅱ型糖尿病,代谢综合征和胰岛素抵抗风险降低有关。但是食用坚果对结肠癌复发和生存的影响尚不清楚。JCO近期发表了一篇文章研究这一问题。

Gastroenterology:根据生活方式、环境及基因因素建立结肠癌风险及起始筛查年龄模型

研究认为,生活方式、环境或遗传风险因素与家族肠癌史一起可对患者的结肠癌风险以及最佳的筛查起始年龄进行预测,是结肠癌预防策略个体化的第一步

CELL HOST MICROBE:细菌为何引起结肠癌

已有的研究显示,致癌细菌有可能具有启动和/或促进结肠癌的能力,该现象部分是通过免疫机制来作用,但是至今为止,我们对此还不完全了解。