ANN RHEUM DIS:南欧人群中系统性红斑狼疮的流行病学和负担

2017-08-07 xiangting MedSci原创

通过使用综合的方法,研究人员对SLE从社区到三级保健的谱系进行了全面描述,几乎一半的病例为轻度,但具有显著损伤。

此前已有一些基于人群的系统性红斑狼疮(SLE)的研究报道,但是缺乏基于社区经个例验证的综合性报道。研究人员研究了1999-2013年间克里特岛SLE的流行病学和负担。

纳入年龄≥15岁的患者。病例符合ACR 1997、SLICC 2012标准并经风湿病医师诊断确定,并通过医学图表、管理和患者生成数据的综合进行验证。

总体年龄调整/性别调整发病率为每10万人年7.4(95%CI为6.8至7.9),女性趋势稳定,但男性增加,平均(±SD)诊断年龄为43(± 15)岁。调整和粗患病率(2013年12月)分别为123.4(113.9至132.9)和143(133-154)/ 105(城市:165/105  VS 农村123/105,P <0.001)。年龄调整/性别调整的肾炎发病率为0.6(0.4-0.8),趋势稳定,而神经精神性SLE为0.5(0.4-0.7)/ 10万人年,并呈增加趋势。虽然一半的流行病例有轻度的表现,但在病程7.2(±6.6)年后30.5%患者出现器官损害,神经精神最常受累,4.4%的肾炎患者发展为终末期肾病。ACR 1997和SLICC 2012分类标准显示高度的一致性(87%),而在约20%的病例中基于医师的诊断早于基于标准的诊断。

通过使用综合的方法,研究人员对SLE从社区到三级保健的谱系进行了全面描述,几乎一半的病例为轻度,但具有显著损伤。SLE并不罕见,主要影响中年女性,并在男性中得到越来越多的认识。神经精神疾病是狼疮预防和治疗中的新兴前沿。

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    2017-08-09 xugumin
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    2017-08-09 zhouqu_8
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    2017-08-07 131****1460

    学习了受益匪浅。

    0

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    2017-08-07 半夏微凉

    学习了谢谢分享

    0

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