Clin Otolaryngol :特发性突聋中3D-FLAIR核磁共振成像的预后值和病理生理意义分析

2019-09-30 AlexYang MedSci原创

特发性突聋(ISSNHL)的潜在病理生理机制仍旧未知。然而,越来越多的观察性研究报道通过使用三维快速液体衰减反转恢复(3D-FLAIR)核磁共振成像(MRI)发现了迷路信号的改变。这些发现需要元分析。最近,有研究人员就利用元分析在ISSNHL患者中评估了3D-FLAIR MRI在鉴定复杂的病理生理机制和预后中的价值。研究共有8个观察性的研究满足他们研究的标准(n=638)。研究人员通过3D-FLA

特发性突聋(ISSNHL)的潜在病理生理机制仍旧未知。然而,越来越多的观察性研究报道通过使用三维快速液体衰减反转恢复(3D-FLAIR)核磁共振成像(MRI)发现了迷路信号的改变。这些发现需要元分析。最近,有研究人员就利用元分析在ISSNHL患者中评估了3D-FLAIR MRI在鉴定复杂的病理生理机制和预后中的价值。

研究共有8个观察性的研究满足他们研究的标准(n=638)。研究人员通过3D-FLAIR成像发现了29%的患者具有高信号强度,表明了复杂的病理(迷路炎(79%),迷路内出血(21%))。另外,3D-FLAIR的高信号强度与基线点更差的听力(SMD: 14dB, 95%CI 5.67-22.94)和眩晕(RR: 1.92, 95%CI 1.16-3.17)相关。多变量分析阐释了高3D-FLAIR信号强度患者的最终听觉纯音均值要低21dB(SMD: 21dB, 95%CI 9.08-33.24)。

最后,研究人员指出,3D-FLAIR成像能够在突聋患者中鉴定最多29%患者的迷路情况,而这些患者之前并不能发现任何的病因。他们的纯音均值要比3D-FLAIR阴性患者低不少于20dB,表明了他们具有更加严重的迷路损伤。他们的发现加深了对ISSNHL病理生理机制的理解。

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