Lancet:前瞻性研究首次表明淋巴丝虫病可明显增加HIV的感染风险

2016-08-03 MedSci MedSci原创

在过去的十年里,关于蠕虫诱导的免疫激活是否会影响对HIV易感的个体一直存在争议。鉴于此,本研究评估了淋巴丝虫病对坦桑尼亚西南部HIV发病率的作用,淋巴丝虫病是一种由班氏丝虫引起的慢性寄生虫病。 在这项以人群为基础的队列研究中,研究人员按地理分层随机选择样本。2006年5月29日至2011年6月16日期间,研究人员共纳入了4283户家庭,涉及约18 000名参与者。所有的家庭成员进行随访和HI

在过去的十年里,关于蠕虫诱导的免疫激活是否会影响对HIV易感的个体一直存在争议。鉴于此,本研究评估了淋巴丝虫病对坦桑尼亚西南部HIV发病率的作用,淋巴丝虫病是一种由班氏丝虫引起的慢性寄生虫病。

在这项以人群为基础的队列研究中,研究人员按地理分层随机选择样本。2006年5月29日至2011年6月16日期间,研究人员共纳入了4283户家庭,涉及约18 000名参与者。所有的家庭成员进行随访和HIV及循环丝虫抗原测试。主要结果为有或无淋巴丝虫病研究对象的HIV发病率。

其中2699名来自Kyela地区的研究对象至少参与了一轮的EMINI研究。1055名最初HIV阴性的青少年和成年研究对象明确伴有淋巴丝虫病,在2626人年中出现32名HIV新感染者。淋巴丝虫病阳性者HIV的感染率(1.91/100人年)明显高于淋巴丝虫病阴性者HIV的感染率(0.80/100人年)。校正年龄和性别后的发病率比为2.17(95%可信区间为1.08-4.37, p=0.0300)。控制其他已知的危险因素后,如性行为和社会经济因素,淋巴丝虫病仍是HIV感染的一个明显的独立的危险因素。

总而言之,该研究为首次表明淋巴丝虫病感染个体其HIV感染的风险显著增加的前瞻性研究。后续研究中仍需要消灭成虫及微丝蚴的免疫学研究和介入治疗研究。

原始出处:

Inge Kroidl, et al., Effect of Wuchereria bancrofti infection on HIV incidence in southwest Tanzania: a prospective cohort study. The Lancet, DOI: http://dx.doi.org/10.1016/S0140-6736(16)31252-1.

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    2017-01-22 howi
  5. [GetPortalCommentsPageByObjectIdResponse(id=2006365, encodeId=84ae20063655c, content=<a href='/topic/show?id=924a3264381' target=_blank style='color:#2F92EE;'>#前瞻性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32643, encryptionId=924a3264381, topicName=前瞻性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5cb32500112, createdName=1508842480_96220437, createdTime=Mon Oct 10 05:42:00 CST 2016, time=2016-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2079178, encodeId=5fda20e917812, content=<a href='/topic/show?id=51e465945e4' target=_blank style='color:#2F92EE;'>#淋巴丝虫病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65945, encryptionId=51e465945e4, topicName=淋巴丝虫病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Thu Mar 16 08:42:00 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077462, encodeId=b02620e7462b8, content=<a href='/topic/show?id=fd8c21045f7' target=_blank style='color:#2F92EE;'>#丝虫病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21045, encryptionId=fd8c21045f7, topicName=丝虫病)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqySEUYKeYDjXJMYMrtscBNkpAnLfQZgDcdkEratcJPqS7ARJOXqllZQhCSFicErlBFbIywuoiaP0LQ/132, createdBy=012d2500132, createdName=ms5880526374914242, createdTime=Tue Feb 28 11:42:00 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828564, encodeId=3c991828564ba, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Jan 22 16:42:00 CST 2017, time=2017-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914436, encodeId=a1e2191443647, content=<a href='/topic/show?id=103f3264681' target=_blank style='color:#2F92EE;'>#前瞻性研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32646, encryptionId=103f3264681, topicName=前瞻性研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e12358, createdName=lhlxtx, createdTime=Wed Feb 08 21:42:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96696, encodeId=89979669620, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160707/IMG577E0499A753A2146.jpg, createdBy=a82f1728003, createdName=Saillong, createdTime=Sun Aug 07 10:57:00 CST 2016, time=2016-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95806, encodeId=c2d1958065f, content=学习一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Aug 04 03:01:00 CST 2016, time=2016-08-04, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2006365, encodeId=84ae20063655c, content=<a href='/topic/show?id=924a3264381' target=_blank style='color:#2F92EE;'>#前瞻性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32643, encryptionId=924a3264381, topicName=前瞻性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5cb32500112, createdName=1508842480_96220437, createdTime=Mon Oct 10 05:42:00 CST 2016, time=2016-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2079178, encodeId=5fda20e917812, content=<a href='/topic/show?id=51e465945e4' target=_blank style='color:#2F92EE;'>#淋巴丝虫病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65945, encryptionId=51e465945e4, topicName=淋巴丝虫病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Thu Mar 16 08:42:00 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077462, encodeId=b02620e7462b8, content=<a href='/topic/show?id=fd8c21045f7' target=_blank style='color:#2F92EE;'>#丝虫病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21045, encryptionId=fd8c21045f7, topicName=丝虫病)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqySEUYKeYDjXJMYMrtscBNkpAnLfQZgDcdkEratcJPqS7ARJOXqllZQhCSFicErlBFbIywuoiaP0LQ/132, createdBy=012d2500132, createdName=ms5880526374914242, createdTime=Tue Feb 28 11:42:00 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828564, encodeId=3c991828564ba, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Jan 22 16:42:00 CST 2017, time=2017-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914436, encodeId=a1e2191443647, content=<a href='/topic/show?id=103f3264681' target=_blank style='color:#2F92EE;'>#前瞻性研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32646, encryptionId=103f3264681, topicName=前瞻性研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e12358, createdName=lhlxtx, createdTime=Wed Feb 08 21:42:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96696, encodeId=89979669620, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160707/IMG577E0499A753A2146.jpg, createdBy=a82f1728003, createdName=Saillong, createdTime=Sun Aug 07 10:57:00 CST 2016, time=2016-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95806, encodeId=c2d1958065f, content=学习一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Aug 04 03:01:00 CST 2016, time=2016-08-04, status=1, ipAttribution=)]
    2016-08-07 Saillong

    赞一个

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2006365, encodeId=84ae20063655c, content=<a href='/topic/show?id=924a3264381' target=_blank style='color:#2F92EE;'>#前瞻性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32643, encryptionId=924a3264381, topicName=前瞻性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5cb32500112, createdName=1508842480_96220437, createdTime=Mon Oct 10 05:42:00 CST 2016, time=2016-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2079178, encodeId=5fda20e917812, content=<a href='/topic/show?id=51e465945e4' target=_blank style='color:#2F92EE;'>#淋巴丝虫病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65945, encryptionId=51e465945e4, topicName=淋巴丝虫病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Thu Mar 16 08:42:00 CST 2017, time=2017-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077462, encodeId=b02620e7462b8, content=<a href='/topic/show?id=fd8c21045f7' target=_blank style='color:#2F92EE;'>#丝虫病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21045, encryptionId=fd8c21045f7, topicName=丝虫病)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqySEUYKeYDjXJMYMrtscBNkpAnLfQZgDcdkEratcJPqS7ARJOXqllZQhCSFicErlBFbIywuoiaP0LQ/132, createdBy=012d2500132, createdName=ms5880526374914242, createdTime=Tue Feb 28 11:42:00 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828564, encodeId=3c991828564ba, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Jan 22 16:42:00 CST 2017, time=2017-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914436, encodeId=a1e2191443647, content=<a href='/topic/show?id=103f3264681' target=_blank style='color:#2F92EE;'>#前瞻性研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32646, encryptionId=103f3264681, topicName=前瞻性研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e12358, createdName=lhlxtx, createdTime=Wed Feb 08 21:42:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96696, encodeId=89979669620, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160707/IMG577E0499A753A2146.jpg, createdBy=a82f1728003, createdName=Saillong, createdTime=Sun Aug 07 10:57:00 CST 2016, time=2016-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95806, encodeId=c2d1958065f, content=学习一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Aug 04 03:01:00 CST 2016, time=2016-08-04, status=1, ipAttribution=)]
    2016-08-04 1dd8c52fm63(暂无匿称)

    学习一下!

    0