Mayo Clin Proc:血钙低,心源性猝死风险增加

2017-10-18 许菁 “中国循环杂志”微信号

哈佛大学医学院Brigham妇女医院研究者发现,较低的血清钙水平增加心脏骤停的风险,即使是在正常范围。

哈佛大学医学院Brigham妇女医院研究者发现,较低的血清钙水平增加心脏骤停的风险,即使是在正常范围。

研究者发现,本研究中的267例心脏骤停患者在90天内的血钙水平低于正常对照组(9.18 mg/dl vs 9.27 mg/dl)。

进一步分析显示,血钙水平每降低1 mg/dl,心源性猝死风险增加1.6倍。与血钙水平高于9.55 mg/dl相比,血钙水平低于8.95 mg/ml,心源性猝死风险增加2.3倍。

而且,心源性猝死患者出现QT间期延长[(465±37) ms vs (425±33 ms)],这支持血钙水平低会导致心律失常的发生。

研究者说,虽然无法明确血钙水平低到什么程度才会有危险,但是从该研究结果来看,即使血钙水平处于正常水平,心源性猝死风险都有可能加倍。

据研究者分析,血钙水平低导致心源性猝死的机制可能是低血钙会导致心力衰竭和舒张功能障碍,而且低钙会增加细胞内的钙超载,这在心肌缺血时导致细胞死亡,,此外,低钙血症会引起甲状旁腺激素分泌影响心血管功能。

原始出处:

Yarmohammadi, H., et al., Serum Calcium and Risk of Sudden Cardiac Arrest in the General Population. Mayo Clin Proc, 2017. 92(10): p. 1479-1485.

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    2018-07-16 linlin2312
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    2017-10-20 andy2091
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    2017-10-20 mhm295
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    2017-10-20 sunylz

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