Diabetes Care:中量果糖蔗糖改善胰岛素敏感性

2012-09-05 高晓方 医学论坛网

  瑞士学者的一项研究表明,与同等量葡萄糖相比,中等量果糖和蔗糖可显著改善肝脏胰岛素敏感性和脂类代谢。论文于2012年8月28日在线发表于《糖尿病护理》(Diabetes Care)杂志。   此项双盲、随机、交叉试验共纳入9例体重正常的男性健康志愿者。所有受试者在3周时间内均应用四种不同的甜味饮料(中果糖、高果糖、高葡萄糖和高蔗糖)。利用高胰岛素-正葡萄糖钳夹技术测定内源性葡萄糖生成

  瑞士学者的一项研究表明,与同等量葡萄糖相比,中等量果糖和蔗糖可显著改善肝脏胰岛素敏感性和脂类代谢。论文于2012年8月28日在线发表于《糖尿病护理》(Diabetes Care)杂志。

  此项双盲、随机、交叉试验共纳入9例体重正常的男性健康志愿者。所有受试者在3周时间内均应用四种不同的甜味饮料(中果糖、高果糖、高葡萄糖和高蔗糖)。利用高胰岛素-正葡萄糖钳夹技术测定内源性葡萄糖生成。

  结果显示,高果糖饮用后的葡萄糖生成肝脏移植显著低于高葡萄糖饮用后,但不同干预时空腹血糖、胰岛素和C肽无差异。与高葡萄糖相比,中果糖、高果糖和高蔗糖饮用后的LDL胆固醇和总胆固醇显著升高;中果糖饮用后的游离脂肪酸显著升高。受试者在干预期间的能量摄入与基线摄入无显著差异。

  链接:

Aeberli I, Hochuli M, Gerber PA, Sze L, Murer SB, Tappy L, Spinas GA, Berneis K.Moderate Amounts of Fructose Consumption Impair Insulin Sensitivity in Healthy Young Men A randomized controlled trial.Diabetes Care. 2012 Aug 28
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    2013-04-13 baoya
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    2012-09-07 yangfl11