J Hepatol:减肥手术能显著改善肝脏胰岛素敏感性

2013-10-21 MedSci MedSci原创

减肥手术能减轻肥胖患者体重并提高葡萄糖代谢。近日,芬兰图尔库大学芬兰医学系PET中心Heidi Immonen、Jarna C. Hannukainen 等发表论文,旨在研究减肥手术对肝脏胰岛素敏感性的效果。研究指出,减肥手术能显著改善肝脏胰岛素敏感性:在术后6个月测量时,改善了胰岛素刺激的肝脏葡萄糖摄取,减少了内源性葡萄糖产量。伴随着这些代谢效应的是肝脏体积和脂肪含量的明显减少。总之,糖尿病患者

减肥手术能减轻肥胖患者体重并提高葡萄糖代谢。近日,芬兰图尔库大学芬兰医学系PET中心Heidi Immonen、Jarna C. Hannukainen 等发表论文,旨在研究减肥手术对肝脏胰岛素敏感性的效果。研究指出,减肥手术能显著改善肝脏胰岛素敏感性:在术后6个月测量时,改善了胰岛素刺激的肝脏葡萄糖摄取,减少了内源性葡萄糖产量。伴随着这些代谢效应的是肝脏体积和脂肪含量的明显减少。总之,糖尿病患者肝脏胰岛素敏感性的增加与体重减少相同的非糖尿病患者很相似。该文于2013年9月23日在《肝脏病学杂志》(Journal of Hepatology)上在线发表。研究方法:通过正电子成像术(positron emission tomography,PET)对23例病态肥胖患者(9例糖尿病患者和14例非糖尿病患者)与10名健康无脂肪对照者进行研究,评估肝脏在空腹状态和正糖高胰岛素(钳夹)期间葡萄糖摄取(HGU)情况。使用磁共振波谱成像(Magnetic resonance spectroscopy,MRS)测量肝脏脂肪含量(LFC),使用磁共振成像(MRI)技术获取肝脏体积。在减肥手术[袖状胃切除

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    2014-08-14 baoya
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    2013-10-23 gwc384

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