Am J Clin Nutr:早期母乳喂养对后代端粒长度的影响

2016-07-24 Mechront 译 MedSci原创

背景:端粒长度(TL)是细胞老化的一个标志,其终身消耗的大部分发生于生命前4年。鲜为知的是,儿童端粒缩短的危险因素。目的:生命早期不同喂养和学龄前儿童TL的关系。方法:纳入了121名拉丁美洲的孩子,评估了饮食、喂养和体重相关危险因素与儿童4岁(n = 108)、5岁(n = 92)大小时的TL长度的关系。有77名儿童的喂养变量进行了重复测量。结果:TL平均长度与下列因素有关:4-6周时纯母乳喂养(

背景:端粒长度(TL)是细胞老化的一个标志,其终身消耗的大部分发生于生命前4年。鲜为知的是,儿童端粒缩短的危险因素。

目的:生命早期不同喂养和学龄前儿童TL的关系。

方法:纳入了121名拉丁美洲的孩子,评估了饮食、喂养和体重相关危险因素与儿童4岁(n = 108)、5岁(n = 92)大小时的TL长度的关系。有77名儿童的喂养变量进行了重复测量。

结果:TL平均长度与下列因素有关:4-6周时纯母乳喂养(调整系数:353.85; 95% CI: 72.81, 634.89; P = 0.01)、母亲TL(调整系数:0.32; 95% CI: 0.11, 0.54; P < 0.01)、更老的父亲年龄(调整系数:33.27; 95% CI: 4.10, 62.44; P = 0.03)。4-6周前在母乳或牛奶替代品中加入其它食物或饮品,与4岁和5岁时的平均TL有关(调整系数:-457.01; 95% CI: -720.50, -193.51; P < 0.01)。在4-6周纯母乳喂养和4、5岁时平均TL之间的关系上,6个月大婴儿肥胖和4岁摄入苏打饮料介导了部分作用。3岁时摄入更多的苏打会加上4-5岁时TL的消磨(调整系数:-515.14; 95% CI: -986.06, -41.22; P = 0.03)。

结论:4-6周龄母乳喂养与儿童4、5岁时更长的TL有关,据此推测该时期的母乳喂养可能会对儿童的健康存在长期影响。

原始出处:

Wojcicki JM,et al.Early exclusive breastfeeding is associated with longer telomeres in Latino preschool children.Am J Clin Nutr. 2016 Jul 20. pii: ajcn115428. [Epub ahead of print]

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1664987, encodeId=26ab166498eef, content=<a href='/topic/show?id=c8664008e1a' target=_blank style='color:#2F92EE;'>#喂养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40087, encryptionId=c8664008e1a, topicName=喂养)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ed425881542, createdName=ms1948154235210413, createdTime=Mon Sep 12 17:56:00 CST 2016, time=2016-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=117018, encodeId=0beb11e018b2, content=文章有深度,赞一个。深入学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Sep 09 22:10:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1288619, encodeId=dbec128861953, content=<a href='/topic/show?id=8d20e5696c5' target=_blank style='color:#2F92EE;'>#端粒长度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75696, encryptionId=8d20e5696c5, topicName=端粒长度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Jul 26 10:56:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299524, encodeId=6c2e129952442, content=<a href='/topic/show?id=7a056349485' target=_blank style='color:#2F92EE;'>#母乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63494, encryptionId=7a056349485, topicName=母乳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1b289, createdName=villahu, createdTime=Tue Jul 26 10:56:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94532, encodeId=ef2494532d3, content=母乳很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Jul 24 20:35:00 CST 2016, time=2016-07-24, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1664987, encodeId=26ab166498eef, content=<a href='/topic/show?id=c8664008e1a' target=_blank style='color:#2F92EE;'>#喂养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40087, encryptionId=c8664008e1a, topicName=喂养)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ed425881542, createdName=ms1948154235210413, createdTime=Mon Sep 12 17:56:00 CST 2016, time=2016-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=117018, encodeId=0beb11e018b2, content=文章有深度,赞一个。深入学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Sep 09 22:10:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1288619, encodeId=dbec128861953, content=<a href='/topic/show?id=8d20e5696c5' target=_blank style='color:#2F92EE;'>#端粒长度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75696, encryptionId=8d20e5696c5, topicName=端粒长度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Jul 26 10:56:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299524, encodeId=6c2e129952442, content=<a href='/topic/show?id=7a056349485' target=_blank style='color:#2F92EE;'>#母乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63494, encryptionId=7a056349485, topicName=母乳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1b289, createdName=villahu, createdTime=Tue Jul 26 10:56:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94532, encodeId=ef2494532d3, content=母乳很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Jul 24 20:35:00 CST 2016, time=2016-07-24, status=1, ipAttribution=)]
    2016-09-09 ylzr123

    文章有深度,赞一个。深入学习。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1664987, encodeId=26ab166498eef, content=<a href='/topic/show?id=c8664008e1a' target=_blank style='color:#2F92EE;'>#喂养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40087, encryptionId=c8664008e1a, topicName=喂养)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ed425881542, createdName=ms1948154235210413, createdTime=Mon Sep 12 17:56:00 CST 2016, time=2016-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=117018, encodeId=0beb11e018b2, content=文章有深度,赞一个。深入学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Sep 09 22:10:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1288619, encodeId=dbec128861953, content=<a href='/topic/show?id=8d20e5696c5' target=_blank style='color:#2F92EE;'>#端粒长度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75696, encryptionId=8d20e5696c5, topicName=端粒长度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Jul 26 10:56:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299524, encodeId=6c2e129952442, content=<a href='/topic/show?id=7a056349485' target=_blank style='color:#2F92EE;'>#母乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63494, encryptionId=7a056349485, topicName=母乳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1b289, createdName=villahu, createdTime=Tue Jul 26 10:56:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94532, encodeId=ef2494532d3, content=母乳很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Jul 24 20:35:00 CST 2016, time=2016-07-24, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1664987, encodeId=26ab166498eef, content=<a href='/topic/show?id=c8664008e1a' target=_blank style='color:#2F92EE;'>#喂养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40087, encryptionId=c8664008e1a, topicName=喂养)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ed425881542, createdName=ms1948154235210413, createdTime=Mon Sep 12 17:56:00 CST 2016, time=2016-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=117018, encodeId=0beb11e018b2, content=文章有深度,赞一个。深入学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Sep 09 22:10:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1288619, encodeId=dbec128861953, content=<a href='/topic/show?id=8d20e5696c5' target=_blank style='color:#2F92EE;'>#端粒长度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75696, encryptionId=8d20e5696c5, topicName=端粒长度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Jul 26 10:56:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299524, encodeId=6c2e129952442, content=<a href='/topic/show?id=7a056349485' target=_blank style='color:#2F92EE;'>#母乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63494, encryptionId=7a056349485, topicName=母乳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1b289, createdName=villahu, createdTime=Tue Jul 26 10:56:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94532, encodeId=ef2494532d3, content=母乳很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Jul 24 20:35:00 CST 2016, time=2016-07-24, status=1, ipAttribution=)]
    2016-07-26 villahu
  5. [GetPortalCommentsPageByObjectIdResponse(id=1664987, encodeId=26ab166498eef, content=<a href='/topic/show?id=c8664008e1a' target=_blank style='color:#2F92EE;'>#喂养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40087, encryptionId=c8664008e1a, topicName=喂养)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ed425881542, createdName=ms1948154235210413, createdTime=Mon Sep 12 17:56:00 CST 2016, time=2016-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=117018, encodeId=0beb11e018b2, content=文章有深度,赞一个。深入学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Sep 09 22:10:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1288619, encodeId=dbec128861953, content=<a href='/topic/show?id=8d20e5696c5' target=_blank style='color:#2F92EE;'>#端粒长度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75696, encryptionId=8d20e5696c5, topicName=端粒长度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Jul 26 10:56:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299524, encodeId=6c2e129952442, content=<a href='/topic/show?id=7a056349485' target=_blank style='color:#2F92EE;'>#母乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63494, encryptionId=7a056349485, topicName=母乳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1b289, createdName=villahu, createdTime=Tue Jul 26 10:56:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94532, encodeId=ef2494532d3, content=母乳很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Jul 24 20:35:00 CST 2016, time=2016-07-24, status=1, ipAttribution=)]
    2016-07-24 1dd8c52fm63(暂无匿称)

    母乳很重要!

    0

相关资讯

Circ Res: PPIs可加速血管内皮细胞的老化

Circ Res: PPIs可加速血管内皮细胞的老化近日来自休斯敦卫理公会研究院的一项新的研究揭示了质子泵抑制剂诱导身体健康问题的机制,该研究已发表于Circulation Research。质子泵抑制剂(PPI)是治疗胃食管反流的常用药物,目前供患者长期使用而并没有医疗监督。最近的研究结果表明,PPI的使用与心血管、肾脏和神经系统疾病的发生有关。该研究探究了PPIs对患者血管内皮功能障碍和老化的

JAMA Neurol:端粒缩短和阿尔兹海默氏症发病风险之间存在因果关联

图片来源:med.stanford.edu 一项发表在国际杂志JAMA Neurol上的研究论文中,来自瑞典卡罗琳学院的科学家们通过研究发现,染色体端粒的缩短或和引发阿尔兹海默氏症激活机制之间存在统计学上的关系,然而这种效应较小,而且并不能利用端粒的长度来评估个体患阿尔兹海默氏症的水平。 我们机体中的每一个细胞都包含有整个基因组,基因组以形成46条染色体的形式包裹于细胞核中,当细胞分裂时染

PLOS One:女性多生孩子可延缓衰老

虽然做母亲是一个非常有价值的经历,但是大部分母亲并不认为不眠之夜和发脾气可有利于延缓衰老。然而,据发表于PLoS ONE的一项新的研究发现表明,女性生育的孩子越多,衰老的速度越慢。

Nature提出细胞自毁新学说

我们染色体末端的特殊结构——端粒决定了细胞可以在多长的时间里继续复制自身。长期以来人们一直在研究它与衰老过程和癌症的关联。现在来自Salk研究所的一个研究发现表明,在细胞阻止肿瘤的自毁程序中端粒有可能比以往认为的要更加重要,有可能可以利用这一功能来改善癌症治疗。这项研究发布在《自然》(Nature)杂志上。当细胞在有丝分裂过程中进行复制时,它们的端粒每次都会缩短一点点。最终,在多次的细胞分裂后,端

J Perinatol:母亲受教育程度影响孩子端粒长度,别让孩子输在起跑线上!

端粒缩短为自然现象。研究表明,机体出现心理问题和压力可加快这一进程。既往研究表明,新生儿端粒的长度各有不同,这可能由于遗传因素和一些外因(如母亲吸烟、吸毒或者怀孕期间营养缺乏)等造成。

Sleep:年迈失眠老人端粒长度缩短速度加快

目的失眠,尤其是晚年的失眠可导致细胞老化速度加快,并提高老年人患慢性疾病和死亡的风险。该研究的目的是探讨失眠对端粒长度的影响,进一步衡量细胞老化,以探究失眠是否导致细胞老化的速度超过老人的实际年龄。 方法一共126名平均年龄为60-88岁的老人参与研究。研究人员使用第四版失眠症诊断手册评估参与者是否失眠,其中有45名老人失眠,81位老人组成对照组。同时研究人员通过qPCR方法检测外周血单核细胞(P