JAHA:接受二尖瓣手术的重度缺血性心肌病患者死亡率的预测因子

2017-11-21 xiangting MedSci原创

瘢痕负荷增加和不完全血运重建是MVi重度缺血性心肌病患者死亡率的有力预测指标。

缺血性二尖瓣返流常伴有死亡风险。虽然手术二尖瓣治疗(MVi)可能会改善症状,但尚未证明可改善生存率。这项研究的目的是确定缺血性二尖瓣返流MVi患者死亡率的预测因子。

评估了2002年1月1日至2012年1月1日117例接受心脏磁共振及MVi的连续性重度缺血性心肌病患者(年龄65±10岁)。使用心脏磁共振来评估左心室重构和心肌瘢痕形成。通过超声心动图从近端等速表面积计算有效的返流口面积。随访期间有43人死亡(37%)(中位数62个月)。多变量分析显示,年龄≥70岁(P = 0.013),糖尿病(P = 0.001),血脂异常(P = 0.012),乳头肌疤痕(P = 0.010),不完全血运重建(P= 0.001),总疤痕%×有效返流口面积≥0.20cm 2(P = 0.005)与全因死亡率独立相关。虽然基线时有效返流孔面积<0.2cm2的患者瘢痕每增加10%危险比增加3.3,基线有效返流孔面积≥0.2cm2的患者瘢痕每增加10%,危险比增加9。与有血管存活心肌的患者相比,血运重建不彻底的患者死亡率显著升高(61%vs.28%; P <0.001)。

瘢痕负荷增加和不完全血运重建是MVi重度缺血性心肌病患者死亡率的有力预测指标。心脏磁共振成像可行性分析可确定哪些缺血性二尖瓣返流患者MVi术后的死亡风险最高。

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topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Nov 23 02:47:00 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310657, encodeId=b18d131065eb8, content=<a href='/topic/show?id=25dc1002255e' target=_blank style='color:#2F92EE;'>#预测因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100225, encryptionId=25dc1002255e, topicName=预测因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Thu Nov 23 02:47:00 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463181, encodeId=ce1b1463181f1, content=<a href='/topic/show?id=cff92389310' target=_blank style='color:#2F92EE;'>#二尖瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, 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    2017-11-23 zhaohui6731
  5. [GetPortalCommentsPageByObjectIdResponse(id=1892979, encodeId=bb7a18929e998, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Tue Apr 03 07:47:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983548, encodeId=55641983548da, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, 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  6. 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target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Nov 23 02:47:00 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263347, encodeId=edab26334e09, content=好好学习天天学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Nov 22 12:58:52 CST 2017, time=2017-11-22, status=1, ipAttribution=), 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    2017-11-23 wwzzly
  7. 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  8. 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target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Nov 23 02:47:00 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263347, encodeId=edab26334e09, content=好好学习天天学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Nov 22 12:58:52 CST 2017, time=2017-11-22, status=1, ipAttribution=), 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  9. [GetPortalCommentsPageByObjectIdResponse(id=1892979, encodeId=bb7a18929e998, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Tue Apr 03 07:47:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983548, encodeId=55641983548da, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, 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    2017-11-22 虈亣靌

    好好学习天天学习

    0

  10. 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    2017-11-21 衣带渐宽

    学习

    0

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在冠状动脉疾病,心脏衰竭和严重左心室收缩功能不全患者中,与单纯药物治疗相比,将冠状动脉旁路移植术(CABG)加入到指南指导医学治疗方法中的生存获益仍不清楚。从2002年7月至2007年5月,共有1212例射血分数为35%或以下,患有冠状动脉疾病并可以接收CABG的患者被随机分配接受CABG加药物治疗(CABG组,610例)和单纯药物治疗(药物治疗组,602例)。主要结果是任何原因引起的死亡。主要次

J Thorac Cardiovasc Surg:左心室辅助装置 VS常规手术

  严重的缺血性心肌病(左心室射血分数<25%)和重度缺血性二尖瓣关闭不全的患者单纯药物治疗预后较差。常规意义上,作为目标治疗的左心室辅助装置通常用于常规手术风险太高的患者。近期,发表于The Journal of Thoracic and Cardiovascular Surgery上一篇文章的评估了对于这类患者传统的手术和这个疗

缺血性心肌病易与其他心肌病混淆 如何鉴别诊断?

59岁男性患者,因半个月前无明显诱因出现胸闷、气短、伴咳嗽入院,由超声心电图确诊为冠心病、陈旧性心肌梗死、缺血性心肌病。缺血性心肌病如何与扩张型心肌病鉴别诊断?临床中漏诊误诊的原因有哪些?详见病例要点——

JAMA:对缺血性心肌病患者使用干细胞及骨髓细胞疗法是安全的

芝加哥 – 迈阿密大学米勒医学院的Alan W. Heldman, M.D.及其同事开展了一项研究,旨在检查在罹患缺血性心肌病的病人中所做的经心内膜干细胞注射(TESI)自体间充质干细胞和骨髓单核细胞的安全性。 对缺血性心肌病的一种有效的促再生疗法将能解决许多病人的一个主要的未得到满足的需要。根据文章的背景资料,一个悬而未决的问题是,间充质干细胞是否有着类似的安全性及可能比骨髓单核细胞更大的功效

JAMA:经心肌注射自体间充质干细胞或骨髓单个核细胞治疗缺血性心肌病是安全的(TAC-HFT试验)

    最近基础研究和临床试验表明骨髓来源细胞提取成分,包括单个核骨髓细胞和间充质干细胞可以减轻急性心梗和慢性缺血性心肌病左室重塑。针对缺血性心肌病有效的抑制重塑、促进再生的治疗将会解决许多病人的主要问题。通过培养扩增的骨髓中的间充质干细胞,由于更强的分化能力,推测其可能可以形成异位组织或刺激肿瘤形成,但也拥有比骨髓单个核细胞更强的抗纤维化以及促进再生的能力。间充