Lancet:原发性非小细胞肺癌远端指骨转移-案例分析

2017-05-29 xing.T MedSci原创

手部X线显示左中、右小指远节指骨为溶骨性病变(如图所示)。最近的PET扫描显示无胸外疾病。在缺乏创伤或感染的情况下,该患者被诊断为原发性肺癌溶骨性转移瘤,在左中指末节截肢后经组织学予以证实。术后功能良好,手指无持续疼痛。医务人员采用镇痛治疗右手小指。该患者几个月后死于原发疾病。

患者为一名78岁的男性,因其IIIa期肺鳞癌而到医院就诊治疗。该患者左中指尖出现疼痛、红斑和水肿4周,这严重影响了患者睡眠和手部功能。患者否认既往受过任何创伤,也没有全身感染临床或实验室证据。在两周前,该患者还报告了其对侧小指尖疼痛加重,轻度水肿和出现红斑。

体检发现该患者所有手指为杵状指,手指内在肌在萎缩和扑翼样震颤。左中指腹有红斑,张力较大和严重充血(如图所示)。右小指指腹也充血、水肿,但不严重。左中、右小指对触诊非常疼痛,但其运动范围和功能却无障碍。没有发现任何创伤的迹象。

图 原发性非小细胞肺癌远端指骨转移(a)左中指的侧面图像显示红斑和杵状指。(b)左中指X片。箭头显示远端指骨骨溶解和肿瘤浸润的软组织影。

手部X线显示左中、右小指远节指骨为溶骨性病变(如图所示)。最近的PET扫描显示无胸外疾病。在缺乏创伤或感染的情况下,该患者被诊断为原发性肺癌溶骨性转移瘤,在左中指末节截肢后经组织学予以证实。术后功能良好,手指无持续疼痛。医务人员采用镇痛治疗右手小指。该患者几个月后死于原发疾病。

原始出处:

Richard J Ross, et al.Synchronous distal phalangeal metastases from primary non-small-cell lung cancer.lancet.2017. http://dx.doi.org/10.1016/S0140-6736(17)31288-6

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    2018-01-22 howi
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    2017-06-02 日月生辉

    肺癌远处转移率高,骨转移是其中之一,学习了

    0

  7. 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level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Mon May 29 15:03:21 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-30 杨利洪

    好好学习,天天分享

    0

  8. 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objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue May 30 07:14:50 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204142, encodeId=bb6c20414290, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon May 29 23:06:24 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204043, encodeId=bd3120404318, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Mon May 29 15:03:21 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-30 ylzr123

    感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue May 30 07:14:50 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204142, encodeId=bb6c20414290, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon May 29 23:06:24 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204043, encodeId=bd3120404318, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Mon May 29 15:03:21 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-29 luominglian113

    学习了谢谢分享

    0

  10. 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level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Mon May 29 15:03:21 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-29 dhzzm

    学习了分享了

    0

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