Clin Exp Allergy:大于胎龄儿儿童时期超重会增加哮喘风险!

2017-06-18 xing.T MedSci原创

由此可见,非过敏儿童出生时LGA8岁时超重会增高哮喘的发生风险。如果得到证实,这些研究结果表明,非过敏儿童出生时LGA可在生命早期确定哮喘的高危个体。

大于胎龄儿(LGA)是胎儿期增长速度较快的标志也是儿童肥胖的危险因素。无论时LGA还是儿童超重都有可能影响哮喘的发生发展,虽然超重在LGA与儿童哮喘之间相关性的作用尚不清楚。重要的是,最近的研究表明超重和哮喘之间的相关性可能与非过敏性途径有关。如果这也适用于LGA和哮喘之间的关联,LGA和哮喘之间的相关性在过敏性和非过敏性儿童中可能有所不同。近日,过敏性疾病领域权威杂志Clinical and Experimental Allergy上发表了一篇研究文章,研究人员旨在评估LGA与8岁时过敏性和非过敏性儿童哮喘患病率的关系以及明确超重在这种相关性中的作用。

研究人员收集了8岁儿童关于哮喘、人体测量学和过敏的完整数据,并且PIAMA出生队列的1608名参与者的潜在混杂因素也是可用的。研究人员采用调整了潜在混杂因素的Logistic回归分析来估计LGA与过敏性和非过敏性儿童哮喘之间相关性的比值比。超重被评定为LGA和哮喘之间相关性的一个潜在调节因素。

研究人员发现出生LGA与8岁的过敏性和非过敏性儿童哮喘之间并无显著相关性。然而,8岁时超重可以改变8岁时哮喘与LGA之间的关联。在非过敏性的儿童中,出生时LGA的儿童以及8岁时超重会显著增加哮喘的发生几率,相比于非LGA儿童和非超重儿童(调整的比值比为7.04;95%可信区间为2.2-24)。

由此可见,非过敏儿童出生时LGA8岁时超重会增高哮喘的发生风险。如果得到证实,这些研究结果表明,非过敏儿童出生时LGA可在生命早期确定哮喘的高危个体。

原始出处:

Leonardo A. Pinto,et al. Increased risk of asthma in overweight children born large for gestational age.Clin Exp Allergy. 2017. http://onlinelibrary.wiley.com/doi/10.1111/cea.12961/full

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    2017-06-20 膀胱癌
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    2017-06-18 忠诚向上

    好好学习努力向上

    0

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    2017-06-18 1ddf0692m34(暂无匿称)

    好文章,有意思

    0