Eur Heart J-Card Img:无症状糖尿病患者冠状动脉病变的非侵入性筛查!

2018-02-20 xing.T MedSci原创

由此可见,与标准治疗相比,非侵入性CAD筛查可降低无症状糖尿病患者27%的心脏事件发生,主要是通过减少非致死性MI和HF住院治疗所致。

无症状糖尿病患者冠状动脉病变(CAD)非侵入性筛查是否可以改善心脏预后尚不清楚。近日,心血管领域权威杂志Eur Heart J-Card Img上发表了一篇研究文章,研究人员围绕这一主题对随机对照试验(RCT)进行了系统的文献回顾和荟萃分析。

研究人员检索了五个在线数据库(PubMed/MEDLINE、Cochrane图书馆、EMbase、Scopus、和Web of Science),检索时间从2000年1月到2017年11月,查找合适的RCT,以及41篇最新的综述。两名研究人员独立地使用标准化形式提取和评估研究数据。其他未发表的数据来自于试验作者。该研究的主要终点为任何心脏事件,综合了心源性死亡、非致死性心肌梗死(MI)、不稳定型心绞痛(UA)或心力衰竭(HF)住院治疗。研究人员使用Mantel-Haenszel法进行了一项荟萃分析得到了相对风险(RR)和95%可信区间(CI)。

研究人员纳入了五项RCT,包含3299例患者,其中189例(5.7%)患者随访期间(加权的平均时间为4.1 年)经历了任何心脏事件。非侵入性CAD筛查显著降低27%的任何心脏事件(RR 为0.73,95%CI为0.55-0.97,P=0.028,需要筛查的人数为56]。这个结果是由重要的、尽管不显著降低非致死性心肌梗死[RR为0.65(95%C为0.41-1.02),P=0.062]和HF住院[RR为0.61(95%CI为0.33-1.10),P=0.100]所驱动。非侵入性CAD筛查并没有显着影响心脏死亡[RR为0.92(95%CI为0.53-1.60),P=0.77]和UA[RR为0.73(95%CI为0.41-1.31),P=0.29]。

由此可见,与标准治疗相比,非侵入性CAD筛查可降低无症状糖尿病患者27%的心脏事件发生,主要是通过减少非致死性MI和HF住院治疗所致。 

原始出处:


Olivier F Clerc,et al. Non-invasive screening for coronary artery disease in asymptomatic diabetic patients: a systematic review and meta-analysis of randomised controlled trials.Eur Heart J-Card Img. 2018. https://doi.org/10.1093/ehjci/jey014

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    2018-02-24 惠映实验室

    学习.谢谢分享.

    0

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    2018-02-22 zhaojie88
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    2018-02-22 slcumt
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    2018-02-21 yfjms

    学习

    0