Stroke:高中性粒细胞与淋巴细胞比值可预测卒中相关肺炎

2018-07-02 xing.T MedSci原创

由此可见,该研究证实了较高的NLR可预测急性缺血性卒中患者的SAP。NLR可能有助于及时发现高危患者,并为预防性抗生素治疗的进一步研究提供线索。

虽然卒中相关性肺炎(SAP)存在多种危险因素和预测模型,但仍然需要更客观、更易获取的标记。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,在这项研究中,研究人员评估了急性缺血性卒中患者中性粒细胞与淋巴细胞比率(NLR)与SAP之间的关系。

研究人员评估了1317例连续就诊的急性缺血性卒中患者。根据修改后的疾病控制和预防中心的标准来定义SAP。根据肺炎严重度指数、快速连续性器官衰竭评估和急性生理学和慢性健康评估II的得分来评估肺炎的严重程度。将绝对嗜中性粒细胞计数除以绝对淋巴细胞计数来计算得到NLR。

在所有患者中,112名(9.0%)患者发生SAP。通过多变量分析在校正混杂因素后,NLR(校正后比值比=1.55; 95%置信区间为1.15-2.11; P=0.005)仍然显著。此外,年龄、房颤、既往卒中史、美国国立卫生研究院卒中量表评分初始评分和高敏C反应蛋白也显著,并且独立于NLR。根据肺炎严重度指数(P<0.001)、快速序贯器官衰竭评估(P<0.001)和急性生理学和慢性健康评估II评分(P=0.004)评估时,重症肺炎组的NLR更高。此外,患有SAP的患者在住院期间和出院后的临床结局更差。

由此可见,该研究证实了较高的NLR可预测急性缺血性卒中患者的SAP。NLR可能有助于及时发现高危患者,并为预防抗生素治疗的进一步研究提供线索。

原始出处:


Ki-Woong Nam.et al. Mensing,et al. High Neutrophil-to-Lymphocyte Ratio Predicts Stroke-Associated Pneumonia.Stroke. 2018. https://doi.org/10.1161/STROKEAHA.118.021228

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    2018-07-05 虈亣靌

    好好学习天天向上认真学习

    0

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    2018-07-03 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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    2018-07-02 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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