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BMJ Open.：系统性回顾儿科拉莫三嗪使用的安全性

2015-06-15 范伟 译 MedSci原创

系统性回顾儿科拉莫三嗪安全性
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目的：识别与儿童拉莫三嗪使用有关的药品不良反应，并与其他抗癫痫药物比较其安全性。 设置：EMBASE数据库(1974 -2015年4月)，MEDLINE(1946 -2015年4月)，PubMed和Cochrane图书馆搜寻的有关拉莫三嗪安全性研究的随机对照试验。 参与者：所有研究涉及的儿科患者≤18岁，包括接受至少单剂量的拉莫三嗪后安全性的临床结果测量。 主要和次要

目的：识别与儿童拉莫三嗪使用有关的药品不良反应，并与其他抗癫痫药物比较其安全性。

设置：EMBASE数据库(1974 -2015年4月)，MEDLINE(1946 -2015年4月)，PubMed和Cochrane图书馆搜寻的有关拉莫三嗪安全性研究的随机对照试验。

参与者：所有研究涉及的儿科患者≤18岁，包括接受至少单剂量的拉莫三嗪后安全性的临床结果测量。

主要和次要结果测量：主要结果测量指标是拉莫三嗪的安全性。拉莫三嗪的药物相互作用是次要结果。

结果：总共78篇文章涉及的儿科患者共有3783名。有2222例不良反应(AEs)报道。皮疹是最常报道的不良反应AE，发生在7.3%的患者身上。史蒂文斯—约翰逊综合征很少报道，每100例有0.09的风险。停药导致的药物不良反应(ADR)在72名儿童(全部治疗患者的1.9%)上有记录。58%的治疗中止归因于不同形式的皮疹，21%是由于癫痫发作的增加。儿童拉莫三嗪单药治疗不良反应AEs的发生率较低。在单药治疗的儿童中头痛(p = 0.02)，嗜睡(< 0.001)，恶心(p = 0.01)，呕吐(p < 0.001)，眩晕(p < 0.001)和腹痛(p = 0.01)显著降低。

结论：皮疹是拉莫三嗪最常见的不良反应，也是最常见治疗中止的原因。儿童接受多药疗法相比单药治疗不良反应 AEs的风险更高。

原始出处：

Egunsola O, Choonara I, Sammons HM. Safety of lamotrigine in paediatrics: a systematic review. BMJ Open. 2015 Jun 12;5(6):e007711. doi: 10.1136/bmjopen-2015-007711.

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    2015-12-28 qingrejiedu

    #系统性#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2016918, encodeId=acce2016918ff, content=<a href='/topic/show?id=9760e69058c' target=_blank style='color:#2F92EE;'>#系统性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76905, encryptionId=9760e69058c, topicName=系统性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2b9b368, createdName=qingrejiedu, createdTime=Mon Dec 28 00:05:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1653953, encodeId=9fc4165395300, content=<a href='/topic/show?id=780f5616430' target=_blank style='color:#2F92EE;'>#拉莫三嗪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56164, encryptionId=780f5616430, topicName=拉莫三嗪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=81de24418640, createdName=zchen, createdTime=Thu Jul 23 20:05:00 CST 2015, time=2015-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847681, encodeId=94df184e681f6, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sat Sep 12 19:05:00 CST 2015, time=2015-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725862, encodeId=93a01e258627e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Sep 03 20:05:00 CST 2015, time=2015-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29896, encodeId=585829896f5, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Mon Jun 29 18:19:00 CST 2015, time=2015-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29321, encodeId=b6532932133, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu Jun 25 23:28:00 CST 2015, time=2015-06-25, status=1, ipAttribution=)]
    2015-07-23 zchen

    #拉莫三嗪#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2016918, encodeId=acce2016918ff, content=<a href='/topic/show?id=9760e69058c' target=_blank style='color:#2F92EE;'>#系统性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76905, encryptionId=9760e69058c, topicName=系统性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2b9b368, createdName=qingrejiedu, createdTime=Mon Dec 28 00:05:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1653953, encodeId=9fc4165395300, content=<a href='/topic/show?id=780f5616430' target=_blank style='color:#2F92EE;'>#拉莫三嗪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56164, encryptionId=780f5616430, topicName=拉莫三嗪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=81de24418640, createdName=zchen, createdTime=Thu Jul 23 20:05:00 CST 2015, time=2015-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847681, encodeId=94df184e681f6, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sat Sep 12 19:05:00 CST 2015, time=2015-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725862, encodeId=93a01e258627e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Sep 03 20:05:00 CST 2015, time=2015-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29896, encodeId=585829896f5, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Mon Jun 29 18:19:00 CST 2015, time=2015-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29321, encodeId=b6532932133, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu Jun 25 23:28:00 CST 2015, time=2015-06-25, status=1, ipAttribution=)]
    2015-09-12 gaoxiaoe

    #BMJ#

    0

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    2015-09-03 feather89

    #PE#

    0

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    2015-06-29 owlhealth

    不错不错

    0

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    2015-06-25 huaxipanxing

    看看

    0