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CCR7预示SCC颈部淋巴结转移

2012-09-25 网络 网络

CCR7口腔鳞状细胞癌SCC淋巴结转移
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根据对60例成人患者的资料分析，趋化因子受体CCR7表达可预示口腔鳞状细胞癌(SCC)颈部淋巴结转移。 加州大学戴维斯分校的Levi G. Ledgerwood博士在美国耳鼻喉-头颈外科学会基金会(AAO-HNSF)2012年会上报告指出，SCC转移扩散较为常见，但其机理尚不清楚。近期研究集中于血流和外周组织T细胞进入淋巴道所必须的细胞表面分子—趋化因子受体CCR7。既往研究提示，CCR7

根据对60例成人患者的资料分析，趋化因子受体CCR7表达可预示口腔鳞状细胞癌(SCC)颈部淋巴结转移。

加州大学戴维斯分校的Levi G. Ledgerwood博士在美国耳鼻喉-头颈外科学会基金会(AAO-HNSF)2012年会上报告指出，SCC转移扩散较为常见，但其机理尚不清楚。近期研究集中于血流和外周组织T细胞进入淋巴道所必须的细胞表面分子—趋化因子受体CCR7。既往研究提示，CCR7可能在多种癌症淋巴结转移过程中扮演重要角色。


组织标本显示CCR7表达阳性

Ledgerwood博士及其同事考察了一家医院2006~2011年收治的60例口腔SCC手术切除患者的组织标本，其中包括30份转移患者和30份未转移患者的标本。每组男性患者均较多，未见组间人口统计学显著差异。淋巴结阳性和阴性患者各30例。

总体上，颈部转移患者CCR7表达率明显高于未转移者(P<0.001)。共计97%的淋巴结阳性患者CCR7表达阳性，但无颈部转移患者仅为43%。对转移患者淋巴结样本检查结果显示，所有30例淋巴结阳性患者均有CCR7表达。


组织标本显示CCR7表达阴性
 
研究者指出，尽管这项研究存在样本量较小的局限性，但结果表明CCR7可能在T细胞进入淋巴道的过程中发挥作用。此外，虽然这是一项初步研究，但仍提示CCR7是值得关注的潜在治疗靶点，并有助于预测肿瘤行为。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1987633, encodeId=400e198e63377, content=<a href='/topic/show?id=67dd1596982' target=_blank style='color:#2F92EE;'>#SCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15969, encryptionId=67dd1596982, topicName=SCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Tue Feb 26 16:22:00 CST 2013, time=2013-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1292921, encodeId=f2f71292921c2, content=<a href='/topic/show?id=df626600877' target=_blank style='color:#2F92EE;'>#淋巴结#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66008, encryptionId=df626600877, topicName=淋巴结)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Thu Sep 27 07:22:00 CST 2012, time=2012-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302487, encodeId=5846130248eb4, content=<a href='/topic/show?id=7be06602886' target=_blank style='color:#2F92EE;'>#淋巴结转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66028, encryptionId=7be06602886, topicName=淋巴结转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Thu Sep 27 07:22:00 CST 2012, time=2012-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589668, encodeId=7ba61589668f0, content=<a href='/topic/show?id=124d10065220' target=_blank style='color:#2F92EE;'>#颈部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100652, encryptionId=124d10065220, topicName=颈部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c46a17776631, createdName=木头人519, createdTime=Thu Sep 27 07:22:00 CST 2012, time=2012-09-27, status=1, ipAttribution=)]
    2013-02-26 zutt

    #SCC#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1987633, encodeId=400e198e63377, content=<a href='/topic/show?id=67dd1596982' target=_blank style='color:#2F92EE;'>#SCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15969, encryptionId=67dd1596982, topicName=SCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Tue Feb 26 16:22:00 CST 2013, time=2013-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1292921, encodeId=f2f71292921c2, content=<a href='/topic/show?id=df626600877' target=_blank style='color:#2F92EE;'>#淋巴结#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66008, encryptionId=df626600877, topicName=淋巴结)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Thu Sep 27 07:22:00 CST 2012, time=2012-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302487, encodeId=5846130248eb4, content=<a href='/topic/show?id=7be06602886' target=_blank style='color:#2F92EE;'>#淋巴结转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66028, encryptionId=7be06602886, topicName=淋巴结转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Thu Sep 27 07:22:00 CST 2012, time=2012-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589668, encodeId=7ba61589668f0, content=<a href='/topic/show?id=124d10065220' target=_blank style='color:#2F92EE;'>#颈部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100652, encryptionId=124d10065220, topicName=颈部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c46a17776631, createdName=木头人519, createdTime=Thu Sep 27 07:22:00 CST 2012, time=2012-09-27, status=1, ipAttribution=)]
    2012-09-27 sodoo

    #淋巴结#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1987633, encodeId=400e198e63377, content=<a href='/topic/show?id=67dd1596982' target=_blank style='color:#2F92EE;'>#SCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15969, encryptionId=67dd1596982, topicName=SCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Tue Feb 26 16:22:00 CST 2013, time=2013-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1292921, encodeId=f2f71292921c2, content=<a href='/topic/show?id=df626600877' target=_blank style='color:#2F92EE;'>#淋巴结#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66008, encryptionId=df626600877, topicName=淋巴结)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Thu Sep 27 07:22:00 CST 2012, time=2012-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302487, encodeId=5846130248eb4, content=<a href='/topic/show?id=7be06602886' target=_blank style='color:#2F92EE;'>#淋巴结转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66028, encryptionId=7be06602886, topicName=淋巴结转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Thu Sep 27 07:22:00 CST 2012, time=2012-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589668, encodeId=7ba61589668f0, content=<a href='/topic/show?id=124d10065220' target=_blank style='color:#2F92EE;'>#颈部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100652, encryptionId=124d10065220, topicName=颈部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c46a17776631, createdName=木头人519, createdTime=Thu Sep 27 07:22:00 CST 2012, time=2012-09-27, status=1, ipAttribution=)]
    2012-09-27 snf701207

    #淋巴结转移#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1987633, encodeId=400e198e63377, content=<a href='/topic/show?id=67dd1596982' target=_blank style='color:#2F92EE;'>#SCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15969, encryptionId=67dd1596982, topicName=SCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Tue Feb 26 16:22:00 CST 2013, time=2013-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1292921, encodeId=f2f71292921c2, content=<a href='/topic/show?id=df626600877' target=_blank style='color:#2F92EE;'>#淋巴结#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66008, encryptionId=df626600877, topicName=淋巴结)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Thu Sep 27 07:22:00 CST 2012, time=2012-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302487, encodeId=5846130248eb4, content=<a href='/topic/show?id=7be06602886' target=_blank style='color:#2F92EE;'>#淋巴结转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66028, encryptionId=7be06602886, topicName=淋巴结转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Thu Sep 27 07:22:00 CST 2012, time=2012-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589668, encodeId=7ba61589668f0, content=<a href='/topic/show?id=124d10065220' target=_blank style='color:#2F92EE;'>#颈部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100652, encryptionId=124d10065220, topicName=颈部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c46a17776631, createdName=木头人519, createdTime=Thu Sep 27 07:22:00 CST 2012, time=2012-09-27, status=1, ipAttribution=)]
    2012-09-27 木头人519

    #颈部#

    0