J Crit Care:血管加压素联合氢化可的松对休克患者血流动力学紊乱的影响

2017-07-25 MedSci MedSci原创

本研究的主要目的是评价对于难治性感染性休克发生短期血流动力学紊乱的患者,血管加压素(AVP)联合氢化可的松(HCT)治疗和其单独治疗疗效的影响。

本研究的主要目的是评价对于难治性感染性休克发生短期血流动力学紊乱的患者,血管加压素(AVP)联合氢化可的松(HCT)治疗和其单独治疗疗效的影响。

这是一项回顾性队列研究,研究对象为成年感染性休克患者。经静脉持续泵入血管加压素0.04u/min和/或氢化可的松200-300mg/d。感染性休克定义为收缩压<90mmHg或平均动脉压(MAP)<70mmHg,不考虑是否需要液体复苏及去甲肾上腺素。

共对300名患者进行了研究。血管加压素联合氢化可的松组治疗4h后"反应"(去甲肾上腺素剂量减少≥50%,MAP无明显下降)率比单独接受血管加压素或氢化可的松组明显升高(P= 0.0005)。在12h(P=0.052)、24h(p=0.036)时,联合用药组反应率均较单一用药组高。用药后4h对各组数据进行多变量回归分析显示反应率与治疗方案独立关联。

所以我们可得出结论:相比较单独用药来说,血管加压素联合氢化可的松可迅速地改善难治性感染性休克中儿茶酚胺匮乏状态。

原始出处:

Buckley MS1, MacLaren R2. Concomitant vasopressin and hydrocortisone therapy on short-term hemodynamic effects and vasopressor requirements in refractory septic shock. J Crit Care. 2017 Jun 17;42:6-11. doi: 10.1016/j.jcrc.2017.06.016.

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    2017-08-03 fyxzlh
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    2017-07-26 hhh678

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