JACC:先天性心脏疾病(CHD)患儿接受非心脏手术后死亡危险增加

2016-02-16 MedSci MedSci原创

目前先天性心脏疾病(CHD)患儿的诊断和治疗已经取得重大的进步,使得很多患儿有了更长的预期寿命,越来越多的患儿需要非心脏手术。本研究旨在比较有和没有CHD儿童接受非心脏手术后死亡率和主要不良术后结果的发生率。数据来源于美国国立外科医师学会2012个儿科数据库的数据。倾向评分匹配后,并通过冠心病分层,死亡率和不良的手术后效果的严重性通过对照组和CHD儿童先心病进行比较。在数据库中的51008名儿童中

目前先天性心脏疾病(CHD)患儿的诊断和治疗已经取得重大的进步,使得很多患儿有了更长的预期寿命,越来越多的患儿需要非心脏手术。

本研究旨在比较有和没有CHD儿童接受非心脏手术后死亡率和主要不良术后结果的发生率。

数据来源于美国国立外科医师学会2012个儿科数据库的数据。倾向评分匹配后,并通过冠心病分层,死亡率和不良的手术后效果的严重性通过对照组和CHD儿童先心病进行比较。

在数据库中的51008名儿童中,4,520名冠心病儿童接受非心脏手术。倾向评分匹配后,共包括了2,805名轻微CHD儿童,1,272名重大CHD儿童,417名严重CHD儿童。每个亚组的儿童都进行了匹配,并与无CHD的对照组进行了匹配,这些对照组患者都接受了具有复杂性可比较的非心脏手术。与他们匹配的对照组相比,中度(3.9%)和重度(8.2%)CHD儿童总死亡的发生率明显高于对照组(分别为1.7%[P<0.001]和1.2%[P=0.001])。严重CHD患者的30天及总死亡率显著增加(比值比[OR]:8.43,95%置信区间[CI]:2.52至28.21; P<0.001; OR:7.32,95%CI:2.83至18.90;p <0.001)。重大CHD患儿的总体死亡率也显著高于他们的对照组(OR:2.28; 95%CI:1.37〜3.79; P=0.002),而轻微CHD患儿和他们匹配的对照组之间没有差别。

重大的和严重的CHD儿童,接受非心脏手术,与无CHD的儿童相比,死亡的危险性增加。进一步的研究需要确定手术的最佳环境,制定培训的多学科团队护理CHD儿童,并确定管理战略,改进这个高危人群的成果。

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    2016-09-09 hbwxf
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topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Feb 18 05:38:00 CST 2016, time=2016-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1334727, encodeId=17381334e27ec, content=<a href='/topic/show?id=6345459514' target=_blank style='color:#2F92EE;'>#CHD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4595, encryptionId=6345459514, topicName=CHD)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/OKNjeqMuGQiclFVAJtO8Yvicr3uMFOHysUY3EYJses2g3YQKBAT7FzaJwAfeVrbPEPnsiaBAicMAJX7icLdcxzMj0kA/132, createdBy=038e2500100, createdName=ms7517674339485982, createdTime=Thu Feb 18 05:38:00 CST 2016, time=2016-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369225, encodeId=bbe61369225c3, content=<a 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442797, encodeId=b9dd1442e9710, content=<a href='/topic/show?id=4198633567d' target=_blank style='color:#2F92EE;'>#死亡危险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63356, encryptionId=4198633567d, topicName=死亡危险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63604994803, createdName=1696533704_45270455, createdTime=Thu Feb 18 05:38:00 CST 2016, time=2016-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488264, encodeId=ac57148826424, content=<a href='/topic/show?id=f37799413a6' target=_blank style='color:#2F92EE;'>#非心脏手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99413, encryptionId=f37799413a6, topicName=非心脏手术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Feb 18 05:38:00 CST 2016, time=2016-02-18, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1819255, encodeId=2b7d1819255d4, content=<a href='/topic/show?id=aba89940943' target=_blank style='color:#2F92EE;'>#非心脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99409, encryptionId=aba89940943, topicName=非心脏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=917c196, createdName=sjzlzc007, createdTime=Wed Mar 16 13:38:00 CST 2016, time=2016-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819368, encodeId=3024181936860, content=<a href='/topic/show?id=210c9941411' target=_blank style='color:#2F92EE;'>#非心脏手术后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99414, encryptionId=210c9941411, topicName=非心脏手术后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442797, encodeId=b9dd1442e9710, content=<a href='/topic/show?id=4198633567d' target=_blank style='color:#2F92EE;'>#死亡危险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63356, encryptionId=4198633567d, topicName=死亡危险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63604994803, createdName=1696533704_45270455, createdTime=Thu Feb 18 05:38:00 CST 2016, time=2016-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488264, encodeId=ac57148826424, content=<a href='/topic/show?id=f37799413a6' target=_blank style='color:#2F92EE;'>#非心脏手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99413, encryptionId=f37799413a6, topicName=非心脏手术)], attachment=null, 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  6. [GetPortalCommentsPageByObjectIdResponse(id=1819255, encodeId=2b7d1819255d4, content=<a href='/topic/show?id=aba89940943' target=_blank style='color:#2F92EE;'>#非心脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99409, encryptionId=aba89940943, topicName=非心脏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=917c196, createdName=sjzlzc007, createdTime=Wed Mar 16 13:38:00 CST 2016, time=2016-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819368, encodeId=3024181936860, content=<a href='/topic/show?id=210c9941411' target=_blank style='color:#2F92EE;'>#非心脏手术后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99414, encryptionId=210c9941411, topicName=非心脏手术后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, 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href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Thu Feb 18 05:38:00 CST 2016, time=2016-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395352, encodeId=193b13953524d, content=<a href='/topic/show?id=562b51588e6' target=_blank style='color:#2F92EE;'>#心脏疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51588, encryptionId=562b51588e6, topicName=心脏疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=49022500195, createdName=12498e0fm78暂无昵称, createdTime=Thu Feb 18 05:38:00 CST 2016, time=2016-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442797, encodeId=b9dd1442e9710, content=<a href='/topic/show?id=4198633567d' target=_blank style='color:#2F92EE;'>#死亡危险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63356, encryptionId=4198633567d, topicName=死亡危险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63604994803, createdName=1696533704_45270455, createdTime=Thu Feb 18 05:38:00 CST 2016, time=2016-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488264, encodeId=ac57148826424, content=<a href='/topic/show?id=f37799413a6' target=_blank style='color:#2F92EE;'>#非心脏手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99413, encryptionId=f37799413a6, topicName=非心脏手术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Feb 18 05:38:00 CST 2016, time=2016-02-18, status=1, ipAttribution=)]
    2016-02-18 huirong
  7. 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  8. 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  9. 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