JACC:对于无症状严重主动脉瓣狭窄,主动脉瓣置换术优于保守治疗

2015-12-22 崔倩 译 MedSci原创

对于无症状严重主动脉瓣狭窄(AS)患者主动脉瓣置换术(AVR),目前的指南一般建议观察等待,直到症状出现。该研究旨在比较诊断为无症状严重AS患者进行初始AVR vs 保守策略的长期随访结果。在2003年1月和2011年12月之间,研究人员使用了来自一个大型多中心注册登记的连续3815例严重AS患者的数据(主动脉射流速度峰值> 4.0 m/s,或平均动脉压梯度>40mm Hg,或主动脉瓣区&l

对于无症状严重主动脉瓣狭窄(AS)患者的主动脉瓣置换术(AVR),目前的指南一般建议观察等待,直到症状出现。

该研究旨在比较诊断为无症状的严重AS患者进行初始AVR vs 保守策略的长期随访结果。

在2003年1月和2011年12月之间,研究人员使用了来自一个大型多中心注册登记的连续3815例严重AS患者的数据(主动脉射流速度峰值> 4.0 m/s,或平均动脉压梯度>40mm Hg,或主动脉瓣区<1.0cm2)。在1,808例无症状的患者中,初始AVR和保守策略分别选择了291例和1517例患者。中位随访时间为1361天,在2年时随访率90%。582例患者(每组291)的倾向得分匹配队列被作为当前报告主要分析集。

倾向评分-匹配队列的基线特性在很大程度上是具有可比性的,除了稍微较小的年龄和初始AVR组中的更大的AS严重性。在保守治疗组,在随访期间41%的患者进行AVR。初始AVR组的累计5年全因死亡率和心脏衰竭住院率均显著降低于保守治疗组(分别为15.4% vs 26.4%,P=0.009;3.8% vs 19.9%,P<0.001)。

在这个现实案例的分析中,无症状严重AS患者保守治疗的长期结果是令人沮丧的,这可能会通过最初的AVR治疗大幅度改善。

原始出处:

Tomohiko Taniguchi,Takeshi Morimoto,Hiroki Shiomi,et al.Initial Surgical Versus Conservative Strategies in Patients With Asymptomatic Severe Aortic Stenosis,JACC,2015.12.22

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    2016-02-10 yxch48
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    2016-03-25 1ddc978cm67(暂无匿称)

    谢谢,我学习了。

    0

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    2016-01-26 doctording1

    是一篇不错的文章

    0

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    2016-01-26 doctording1

    这篇文章有一定深度

    0

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    2016-08-09 hbwxf
  7. [GetPortalCommentsPageByObjectIdResponse(id=1734606, encodeId=84be1e3460644, content=<a href='/topic/show?id=ffcf2114849' target=_blank style='color:#2F92EE;'>#严重主动脉瓣狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21148, encryptionId=ffcf2114849, topicName=严重主动脉瓣狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54e533785577, createdName=lq0312, createdTime=Mon Jun 13 10:36:00 CST 2016, time=2016-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742349, encodeId=41b51e4234903, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Wed Feb 10 13:36:00 CST 2016, time=2016-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73675, encodeId=c2bae3675d7, content=谢谢,我学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73801651090, createdName=1ddc978cm67(暂无匿称), createdTime=Fri Mar 25 05:57:00 CST 2016, time=2016-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59995, encodeId=d1925999588, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 17:24:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59994, encodeId=f61059994d2, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 17:24:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1853454, encodeId=fa261853454fb, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Tue Aug 09 09:36:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55138, encodeId=e49c55138dd, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 09 22:12:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55135, encodeId=ed7155135e0, content=哦,, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 09 22:11:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55134, encodeId=97ff5513494, content=额…, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 09 22:11:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55136, encodeId=c85a55136df, content=好吧,, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 09 22:11:00 CST 2016, time=2016-01-09, status=1, ipAttribution=)]
    2016-01-09 medsic

    谢谢分享!

    0

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    2016-01-09 medsic

    哦,

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1734606, encodeId=84be1e3460644, content=<a href='/topic/show?id=ffcf2114849' target=_blank style='color:#2F92EE;'>#严重主动脉瓣狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21148, encryptionId=ffcf2114849, topicName=严重主动脉瓣狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54e533785577, createdName=lq0312, createdTime=Mon Jun 13 10:36:00 CST 2016, time=2016-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742349, encodeId=41b51e4234903, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Wed Feb 10 13:36:00 CST 2016, time=2016-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73675, encodeId=c2bae3675d7, content=谢谢,我学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73801651090, createdName=1ddc978cm67(暂无匿称), createdTime=Fri Mar 25 05:57:00 CST 2016, time=2016-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59995, encodeId=d1925999588, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 17:24:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59994, encodeId=f61059994d2, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 17:24:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1853454, encodeId=fa261853454fb, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Tue Aug 09 09:36:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55138, encodeId=e49c55138dd, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 09 22:12:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55135, encodeId=ed7155135e0, content=哦,, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 09 22:11:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55134, encodeId=97ff5513494, content=额…, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 09 22:11:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55136, encodeId=c85a55136df, content=好吧,, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 09 22:11:00 CST 2016, time=2016-01-09, status=1, ipAttribution=)]
    2016-01-09 medsic

    额…

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1734606, encodeId=84be1e3460644, content=<a href='/topic/show?id=ffcf2114849' target=_blank style='color:#2F92EE;'>#严重主动脉瓣狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21148, encryptionId=ffcf2114849, topicName=严重主动脉瓣狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54e533785577, createdName=lq0312, createdTime=Mon Jun 13 10:36:00 CST 2016, time=2016-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742349, encodeId=41b51e4234903, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Wed Feb 10 13:36:00 CST 2016, time=2016-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73675, encodeId=c2bae3675d7, content=谢谢,我学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73801651090, createdName=1ddc978cm67(暂无匿称), createdTime=Fri Mar 25 05:57:00 CST 2016, time=2016-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59995, encodeId=d1925999588, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 17:24:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59994, encodeId=f61059994d2, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 17:24:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1853454, encodeId=fa261853454fb, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Tue Aug 09 09:36:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55138, encodeId=e49c55138dd, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 09 22:12:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55135, encodeId=ed7155135e0, content=哦,, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 09 22:11:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55134, encodeId=97ff5513494, content=额…, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 09 22:11:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55136, encodeId=c85a55136df, content=好吧,, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 09 22:11:00 CST 2016, time=2016-01-09, status=1, ipAttribution=)]
    2016-01-09 medsic

    好吧,

    0