Eur J Heart Fail:研究确定糖尿病的又一致命并发症

2017-06-27 Heather_z727 来宝网

在一项新的研究中,研究人员发现了糖尿病和急性心衰之间的关系。研究人员比对了单纯急性心衰患者和糖尿病急性心衰患者,结果发现,他们与炎症,心血管功能和肾脏健康相关的生物标记物都存在着明显的不同。



糖尿病对急性心力衰竭的重要影响

在一项新的研究中,研究人员发现了糖尿病和急性心衰之间的关系。研究人员比对了单纯急性心衰患者和糖尿病急性心衰患者,结果发现,他们与炎症,心血管功能和肾脏健康相关的生物标记物都存在着明显的不同。

研究人员表示:“目前我们尚不清楚有或者没有糖尿病的心衰患者不同的病理生理过程,因此,我们分析了24小时内一组48循环生物标记,在没有糖尿病的心衰患者中,我们进行了网络分析来确定测量生物标志物之间的相关性。与非糖尿病患者相比(n = 1111),那些患有糖尿病(n = 922)的人更容易患缺血性心脏病,以及传统的冠状动脉。多变量调整后,我们发现,有没有糖尿病的影响和差别很大,一系列的生物标志物都存在着明显的不同,其中包括炎症(TNFR-1a periostin),心肌细胞伸展(BNP),血管生成(VEGFR,血管生成素)和肾功能调整(NGAL KIM-1)(p值< 0.05)。”

对于急性心衰患者而言,有没有糖尿病完全是两种截然不同的情况,网络分析表明心脏重塑,炎症和纤维化都与糖尿病患者密切相关。

此次研究发表于《欧洲心脏病》杂志中,研究结果表明了糖尿病对急性心衰的重大影响,以及在治疗心衰的过程中,应该把是否同时患有糖尿病作为选择治疗方法的重要依据

原始出处:

Abhinav Sharma, Biniyam G. Demissei, Jasper Tromp, et al. A network analysis to compare biomarker profiles in patients with and without diabetes mellitus in acute heart failure, European Journal of Heart Failure (2017). DOI: 10.1002/ejhf.912.


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    2018-02-16 丁鹏鹏
  2. [GetPortalCommentsPageByObjectIdResponse(id=1757804, encodeId=8acb1e578048f, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Fri Feb 16 19:59:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356370, encodeId=36aa13563e0af, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jun 29 00:59:00 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562598, encodeId=32fd15625980d, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Jun 29 00:59:00 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215931, encodeId=21e52159312c, content=糖尿病研究好多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Tue Jun 27 10:50:59 CST 2017, time=2017-06-27, status=1, ipAttribution=)]
    2017-06-29 zhaojie88
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    2017-06-29 slcumt
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    2017-06-27 zwjnj2

    糖尿病研究好多学习

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