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Sci Rep：新型骨水泥或可用于椎体压缩性骨折的治疗

2017-11-27 MedSci MedSci原创

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近年来，越来越多的研究聚焦于研发具有生物活性、可生物降解并具有合适力学性能的新一代注射型骨水泥，用于治疗椎体压缩性骨折（VCFs）。在这项研究中，研究人员制备了一种PSC含量高的PSC/CS复合水泥（植酸衍生的生物活性玻璃），并在体外和体内进行了评估。结果显示，PSC/CS水泥具有较好的可注射性，良好的抗崩解性，不透射线性和合适的机械性能。体外试验表明，该水泥具有生物活性、生物相容性，可持续维持其

近年来，越来越多的研究聚焦于研发具有生物活性、可生物降解并具有合适力学性能的新一代注射型骨水泥，用于治疗椎体压缩性骨折（VCFs）。

在这项研究中，研究人员制备了一种PSC含量高的PSC/CS复合水泥（植酸衍生的生物活性玻璃），并在体外和体内进行了评估。

结果显示，PSC/CS水泥具有较好的可注射性，良好的抗崩解性，不透射线性和合适的机械性能。体外试验表明，该水泥具有生物活性、生物相容性，可持续维持其形态，并为骨再生提供长期的机械支持。动物实验中，兔股骨髁缺损植入水泥后的X线成像、微型计算机断层扫描和组织学证实了水泥的再吸收和骨诱导性。与PMMA和CSPC相比，PSC/CS水泥组的骨水泥界面骨细胞和骨小梁较多。剩余骨水泥的体积表明PSC/CS具有一定的降解能力，吸收率远低于CSPC水泥。

综上所述，该研究结果表明PSC/CS是治疗VCFs的一种很有前景的骨水泥。

原始出处：

Zhu T, Ren H, et al., Novel bioactive glass based injectable bone cement with improved osteoinductivity and its in vivo evaluation. Sci Rep. 2017 Jun 15;7(1):3622. doi: 10.1038/s41598-017-03207-9.

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    2018-01-16 暂20a6e63m

    嗯嗯 新技术革命新方式

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    2018-09-15 12498484m56(暂无昵称)

    #椎体压缩性骨折#

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    2017-11-29 dingxiaobo

    #椎体#

    0

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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Mon Nov 27 19:08:52 CST 2017, time=2017-11-27, status=1, ipAttribution=)]
    2017-11-29 zhs3882

    #骨水泥#

    0

  5. 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    2017-11-28 jihuaijun1112

    学习学习学习

    0

  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Mon Nov 27 19:08:52 CST 2017, time=2017-11-27, status=1, ipAttribution=)]
    2017-11-27 changjiu

    学习一下谢谢

    0

  7. 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attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/20/02e70d8a81756be978c1ac6ecae73990.jpg, createdBy=a0592196997, createdName=暂20a6e63m, createdTime=Mon Nov 27 19:59:11 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264823, encodeId=f8b526482311, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuNreCBwuEU9I5ich0uE1zdHnicdKjEibG64cgLHSp5sMMFMiatLiaDaSrGOj1jAaDuTZo7vDLDhgRFHt6/0, createdBy=caa52003923, createdName=狼毒花1982, createdTime=Mon Nov 27 19:34:04 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264821, encodeId=1cf2264821d9, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Mon Nov 27 19:08:52 CST 2017, time=2017-11-27, status=1, ipAttribution=)]
    2017-11-27 1e0f8808m18(暂无匿称)

    新材料.新方法.造福百姓.

    0

  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Mon Nov 27 21:44:07 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264835, encodeId=0c5b26483592, content=新材料.新方法.造福百姓., beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Mon Nov 27 20:51:59 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264825, encodeId=6f0a264825c9, content=嗯嗯 希望早日应用于临床, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Mon Nov 27 19:08:52 CST 2017, time=2017-11-27, status=1, ipAttribution=)]
    2017-11-27 暂20a6e63m

    嗯嗯 希望早日应用于临床

    0

  9. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Mon Nov 27 19:08:52 CST 2017, time=2017-11-27, status=1, ipAttribution=)]
    2017-11-27 狼毒花1982

    学习了感谢分享

    0

  10. 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attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/20/02e70d8a81756be978c1ac6ecae73990.jpg, createdBy=a0592196997, createdName=暂20a6e63m, createdTime=Mon Nov 27 19:59:11 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264823, encodeId=f8b526482311, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuNreCBwuEU9I5ich0uE1zdHnicdKjEibG64cgLHSp5sMMFMiatLiaDaSrGOj1jAaDuTZo7vDLDhgRFHt6/0, createdBy=caa52003923, createdName=狼毒花1982, createdTime=Mon Nov 27 19:34:04 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264821, encodeId=1cf2264821d9, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Mon Nov 27 19:08:52 CST 2017, time=2017-11-27, status=1, ipAttribution=)]
    2017-11-27 Jackie Li

    学习

    0

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