Int J Nanomed:选择性激光熔融钛的微/纳米表面植体的封闭效果

2018-10-15 MedSci MedSci原创

选择性激光熔化(SLM)钛是制造定制植体的理想选择,具有适当的表面改性可改善植体的生物活性。种植体周围的软组织为下面的骨整合形成保护性组织屏障。因此,应对原始的微粗糙SLM表面进行处理有利于周围软组织的附着。 在这项研究中,阳极氧化(AO)应用于微型SLM钛基板上,形成TiO2纳米管阵列。之后,通过电化学沉积(AOC)将磷酸钙(CaP)纳米颗粒嵌入纳米管或纳米管的区间中。将这两个样品与未处理

选择性激光熔化(SLM)钛是制造定制植体的理想选择,具有适当的表面改性可改善植体的生物活性。种植体周围的软组织为下面的骨整合形成保护性组织屏障。因此,应对原始的微粗糙SLM表面进行处理有利于周围软组织的附着。

在这项研究中,阳极氧化(AO)应用于微型SLM钛基板上,形成TiO2纳米管阵列。之后,通过电化学沉积(AOC)将磷酸钙(CaP)纳米颗粒嵌入纳米管或纳米管的区间中。将这两个样品与未处理(SLM)样品进行比较,并接受机械抛光(MP)SLM钛样品。扫描电子显微镜,能量色散光谱,X射线衍射,表面粗糙度和水接触角测量用于表面表征。培养原代人牙龈上皮细胞(HGEC)和人牙龈成纤维细胞(HGF)用于细胞测定以确定粘附、增殖和粘附相关基因表达。

结果显示,对于HGEC,AOC样品显示出比AO和SLM样品明显更高的粘附、增殖和粘附相关基因表达(P <0.05)。同时,AOC样本显示HGFs的粘附,增殖和粘附相关基因表达最高(P <0.05)。

原始出处:

Ruogu Xu, Xiucheng Hu, et al., Micro-/nano-topography of selective laser melting titanium enhances adhesion and proliferation and regulates adhesion-related gene expressions of human gingival fibroblasts and human gingival epithelial cells. Int J Nanomedicine. 2018; 13: 5045–5057.

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    2019-02-22 30397613
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    2018-10-17 oliver169
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    2018-10-16 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

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