Aging Cell:肌肉状态和年龄无关,和锻炼相关?

2018-03-09 海北 MedSci原创

最近,来自伦敦国王学院的研究人员进行了一项研究,从125名高度活跃的年龄在55-79岁的骑自行车的男性和女性的子集(n = 90)中,研究人员获取了股外侧肌肉活组织检查样品的分析结果。

最近,来自伦敦国王学院的研究人员进行了一项研究,从125名高度活跃的年龄在55-79岁的骑自行车的男性和女性的子集(n = 90)中,研究人员获取了股外侧肌肉活组织检查样品的分析结果。

随后,研究人员尝试揭示肌肉和生理功能之间的关联。其在活检标本中测定了与年龄相关的肌纤维类型和组成(ATP酶组织化学),大小(形态测定),毛细血管密度(免疫组织化学)和线粒体蛋白质含量(蛋白质印迹)。

除了年龄相关的男性毛细血管密度变化(r = -2.99; p = .02)外,肌肉样本中没有其他参数测量显示与年龄相关。

然而,在男性中,I型纤维和毛细血管(p <.05)与训练量,最大摄氧量,摄氧动力学和通气阈值显着相关。在女性中,观察到的唯一关联是在毛细管作用和训练量之间(p <.05)的关联。

在男性中,II型纤维的比例和面积(p <0.05)与骑行中的峰值功率,以及在最大自愿等长收缩期间的最大扭矩发生率相关。线粒体蛋白质含量与男性或女性的任何心肺参数无关(P> 0.05)。

因此,研究人员在这个高度活跃的队列研究中得出结论,几乎没有证据显示在所研究的年龄范围内VL肌肉的性质随年龄变化。相反,部分肌肉特征中与体内生理指标相关。


原始出处:

Ross D. Pollock et al. Properties of the vastus lateralis muscle in relation to age and physiological function in master cyclists aged 55-79 yearsAging Cell, 2018; e12735 DOI: 10.1111/acel.12735


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    2018-10-22 维他命
  2. [GetPortalCommentsPageByObjectIdResponse(id=1960755, encodeId=903f1960e5523, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Oct 22 23:42:00 CST 2018, time=2018-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870487, encodeId=e6ad18e0487a7, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon Aug 06 09:42:00 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294767, encodeId=2dd2294e67f8, content=不错耶.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Sat Mar 10 07:47:15 CST 2018, time=2018-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050285, encodeId=9ee61050285ff, content=运动锻炼应该是健康第一要素,对各类疾病都应该有益。但是国内这方面研究太少, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=jingjing, createdTime=Fri Mar 09 20:42:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294585, encodeId=47cf29458550, content=保持肌肉质量, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSnicyibWfBTADUOjice1wnN8fal65AictjJzXuPFfriafV33NLPOQ6DiahyynUTFBZIrsPTAKwxp2ZbwlshWlCPTEvKiaaibEmr478vA/0, createdBy=3a912053405, createdName=137****8002, createdTime=Fri Mar 09 19:18:53 CST 2018, time=2018-03-09, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1960755, encodeId=903f1960e5523, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Oct 22 23:42:00 CST 2018, time=2018-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870487, encodeId=e6ad18e0487a7, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon Aug 06 09:42:00 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294767, encodeId=2dd2294e67f8, content=不错耶.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Sat Mar 10 07:47:15 CST 2018, time=2018-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050285, encodeId=9ee61050285ff, content=运动锻炼应该是健康第一要素,对各类疾病都应该有益。但是国内这方面研究太少, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=jingjing, createdTime=Fri Mar 09 20:42:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294585, encodeId=47cf29458550, content=保持肌肉质量, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSnicyibWfBTADUOjice1wnN8fal65AictjJzXuPFfriafV33NLPOQ6DiahyynUTFBZIrsPTAKwxp2ZbwlshWlCPTEvKiaaibEmr478vA/0, createdBy=3a912053405, createdName=137****8002, createdTime=Fri Mar 09 19:18:53 CST 2018, time=2018-03-09, status=1, ipAttribution=)]
    2018-03-10 owlhealth

    不错耶.学习了

    0

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    2018-03-09 jingjing

    运动锻炼应该是健康第一要素,对各类疾病都应该有益。但是国内这方面研究太少

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1960755, encodeId=903f1960e5523, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Oct 22 23:42:00 CST 2018, time=2018-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870487, encodeId=e6ad18e0487a7, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon Aug 06 09:42:00 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294767, encodeId=2dd2294e67f8, content=不错耶.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Sat Mar 10 07:47:15 CST 2018, time=2018-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050285, encodeId=9ee61050285ff, content=运动锻炼应该是健康第一要素,对各类疾病都应该有益。但是国内这方面研究太少, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=jingjing, createdTime=Fri Mar 09 20:42:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294585, encodeId=47cf29458550, content=保持肌肉质量, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSnicyibWfBTADUOjice1wnN8fal65AictjJzXuPFfriafV33NLPOQ6DiahyynUTFBZIrsPTAKwxp2ZbwlshWlCPTEvKiaaibEmr478vA/0, createdBy=3a912053405, createdName=137****8002, createdTime=Fri Mar 09 19:18:53 CST 2018, time=2018-03-09, status=1, ipAttribution=)]
    2018-03-09 137****8002

    保持肌肉质量

    0

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