JAMA Pediatr:儿科炎症性肠病的实验室辅助诊断

2017-08-20 zhangfan MedSci原创

粪便钙卫蛋白检测是十分有效的儿科炎症性肠病辅助检测手段

血清标志物及粪便钙卫蛋白可用于儿科炎症性肠病IBD)的诊断。近日研究人员考察了这类实验室标志物的临床诊断价值。

研究人员收集了截至2016年9月的相关研究资料。研究评估超过1种以上血液标志物或粪便钙卫蛋白对IBD诊断的准确性,并采用内镜或组织病理学临床随访对结果进行验证。

8项相关研究以及1120名患儿纳入本次荟萃分析。研究发现血液标志物和粪便钙卫蛋白显著提高儿科IBD患者的分辨率。粪便钙卫蛋白效果最佳,症状的AUC面积提高0.26(95% CI, 0.21-0.31);第二最佳标记为红细胞沉降率,AUC提高0.16(95% CI,0.11-0.21)。将粪便钙卫蛋白检测添加至现有检测标准后,IBD的诊断的准确率由33%上升至91%,误诊率由16%下降至9%。

研究认为,粪便钙卫蛋白检测是十分有效的儿科炎症性肠病辅助检测手段。

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    2017-12-13 feather89
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    2017-08-21 damiao93

    谢谢分享,又学习了

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