Anesthesiology:皮下注射硝酸甘油用于小儿患者桡动脉置管

2020-05-30 “罂粟花”微信号 “罂粟花”微信号

由于血管较小,小儿桡动脉置管具有挑战性。硝酸甘油是一种有效的血管扩张剂,可通过增加桡动脉内径和防止成年患者的血管痉挛来增加桡动脉置管的成功率。本研究旨在验证一假设,即皮下注射硝酸甘油可提高小儿桡动脉置

背景与目的

由于血管较小,小儿桡动脉置管具有挑战性。硝酸甘油是一种有效的血管扩张剂,可通过增加桡动脉内径和防止成年患者的血管痉挛来增加桡动脉置管的成功率。本研究旨在验证一假设,即皮下注射硝酸甘油可提高小儿桡动脉置管的成功率。

方 法

这项双盲、随机、对照、单中心研究纳入了在全麻期间需要桡动脉置管的小儿患者(n=113,年龄小于2岁)。将其随机分为硝酸甘油组(n=57)和对照组(n=56)。全身麻醉诱导后,在超声引导下于所选桡动脉上方皮下注射硝酸甘油溶液(5μg/kg的硝酸甘油0.5ml)或生理盐水(0.5ml),注射时间大于10s。3min后在超声引导下行桡动脉置管。分别在皮下注射硝酸甘油前后和置管后测量桡动脉内径。主要观察指标是首次置管成功率。次要观察指标包括桡动脉内径和包括血肿和血管痉挛在内的总体并发症的发生率。

结 论

小儿桡动脉置管前皮下注射硝酸甘油不仅可提高首次置管成功率,还可降低总体并发症发生率。

原始出处:

Jang YE, Ji SH, Kim EH, et al. Subcutaneous Nitroglycerin for Radial Arterial Catheterization in Pediatric Patients: A Randomized Controlled Trial[J]. Anesthesiology, 2020, undefined: undefined.

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    2020-06-01 skhzy

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