Diabetologia:延长哺乳或可降低产妇糖尿病风险

2014-05-12 desperado-c 丁香园

哺乳对胎儿健康有重要影响,而且,一些研究还发现哺乳可提高产妇的胰岛素敏感性和葡萄糖耐量。然而,哺乳与产妇2型糖尿病风险之间的关系仍不明确。 为此,来自德国糖尿病研究中心的Schulze教授及其团队进行了一项研究,调查哺乳与产妇2型糖尿病风险之间的关系,并探讨这种相关性是否是由人体测量学因素和生化因素介导。该研究结果在线发表在2014年05月01日的Diabetologia杂志上。【原文下载】

哺乳对胎儿健康有重要影响,而且,一些研究还发现哺乳可提高产妇的胰岛素敏感性和葡萄糖耐量。然而,哺乳与产妇2型糖尿病风险之间的关系仍不明确。

为此,来自德国糖尿病研究中心的Schulze教授及其团队进行了一项研究,调查哺乳与产妇2型糖尿病风险之间的关系,并探讨这种相关性是否是由人体测量学因素和生化因素介导。该研究结果在线发表在2014年05月01日的Diabetologia杂志上。【原文下载】

Schulze教授等进行了一项巢式病例对照研究,受试者来自欧洲癌症与营养前瞻性调查——波茨坦研究(EPIC-Potsdam)。包括1262例产后女性,受试者的基线年龄为35-64岁之间。使用调查问卷评估受试者的哺乳时间。留取血液标本测量生化指标,包括HDL-胆固醇、甘油三酯、C反应蛋白、fetuin-A、γ-谷氨酰转移酶和脂联素。

Schulze教授等还系统性检索了已发表的前瞻性队列研究,并进行荟萃分析,探讨哺乳和2型糖尿病风险之间的关系。

该研究发现,在EPIC-Potsdam研究中,受试者哺乳时间每增加6个月,其发生糖尿病的风险比(HR)为0.73。对之间发表三项前瞻性研究和当前研究进行荟萃分析显示,哺乳时间与糖尿病风险呈负相关,与从未哺乳的受试者相比,一生哺乳6–11月受试者发生糖尿病的汇总HR为0.89。校正BMI和腰围后,EPIC-Potsdam研究中,受试者哺乳时间每增加6个月,其发生糖尿病的风险比(HR)为0.80,哺乳时间与糖尿病风险之间的相关性减弱。进一步校正潜在的生物指标后,很大程度上可解释这种相关性。

该研究提示,延长哺乳时间或许可降低糖尿病风险。

原始出处:

Jäger S1, Jacobs S, Kröger J, Fritsche A, Schienkiewitz A, Rubin D, Boeing H, Schulze MB.Breast-feeding and maternal risk of type 2 diabetes: a prospective study and meta-analysis.Diabetologia. 2014 May 1. 【原文下载】

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    2014-11-22 智智灵药
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    2014-05-12 58.52.133.87

    哺乳消耗掉更多的糖?

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近期发表的一项囊括10项随机对照研究的Meta分析表明,对于2型糖尿病患者,与安慰剂相比,钠葡萄糖共同转运蛋白2(SGLT-2)抑制剂依帕列净(empagliflozin)除了能有效降低血糖外,还有助于减轻体重和降低血压。(Diabetes Obes Metab. 2014年4月26日在线版)在该分析中,依帕列净以10 mg或25 mg应用对HbA1c水平的降低效果均显著优于安慰剂,其中25 mg