Allergy:母乳喂养与儿童哮喘相关性研究

2017-04-29 MedSci MedSci原创

一些研究提出母乳喂养可能存在免疫调节的作用,可影响儿童变应性致敏和过敏性疾病的发展。2017年4月29日发表在Allergy杂志上的一篇文章就母乳喂养与儿童过敏性疾病、湿疹、哮喘相关性进行了研究。该研究主要研究的是母乳喂养与儿童变应性致敏性疾病、吸入性或食物过敏、湿疹,之间的关系;以及其相关性是否受到环境因素的暴露不同或母体是否既往患有哮喘、过敏症、湿疹的影响。该研究是在以人群为基础的5828名儿

一些研究提出母乳喂养可能存在免疫调节的作用,可影响儿童变应性致敏和过敏性疾病的发展。2017年4月29日发表在Allergy杂志上的一篇文章就母乳喂养与儿童过敏性疾病、湿疹、哮喘相关性进行了研究。

该研究主要研究的是母乳喂养与儿童变应性致敏性疾病、吸入性或食物过敏、湿疹,之间的关系;以及其相关性是否受到环境因素的暴露不同或母体是否既往患有哮喘、过敏症、湿疹的影响。

该研究是在以人群为基础的5828名儿童中进行的前瞻性的队列研究,从胚胎期即开始进行研究。该研究者通过邮政问卷调查来收集信息,调查内容为婴儿期的母乳喂养的持续时间(< 2个月,2 - 4个月,4 - 6个月和≥6个月)和非纯母乳喂养的时间(4个月)。在这些孩子10岁的时候,使用皮肤过敏试验来检测是否吸入性或食物过敏;并邮寄问卷调查是否有医师诊断的吸入剂过敏或食物过敏。父母亲既往有湿疹病史的,在其后代的出生到10岁期间也可能会出现湿疹。

该研究结果提示,并未发现母乳喂养与任何变应性致敏、医师诊断的过敏性疾病、或与其相关的过敏性的结局相关。母乳喂养的时间过短会增加儿童患有湿疹的风险(p-value for trend <0.05)。与前4个月纯母乳喂养的婴儿相比,非纯母乳喂养的儿童其患有湿疹的总体风险增加(aOR (95% CI): 1.11 (1.01, 1.23))。周期特异性风险敏感性分析提示,给2月龄的湿疹患者使用药膏,对比延迟使用者,结果表明暴露因素的不同对预后的影响不明显。研究结果表明,婴儿的过敏、湿疹、哮喘等疾病与母亲的既往史无明确的相关性。

原始出处:

Elbert NJ,van Meel ER,den Dekker HT,et al.Duration and exclusiveness of breastfeeding and risk of childhood atopic diseases.Allergy. 2017 Apr 27. doi: 10.1111/all.13195.

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    2017-05-01 仁医06
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    2017-05-01 膀胱癌

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