J Biomater Appl:新型石墨烯支架或可用于骨组织工程以促进骨再生

2018-01-20 MedSci MedSci原创

在这项研究中,研究人员使用聚合物泡沫复制技术制备导电的、硼酸盐基的多孔13-93B3生物活性玻璃复合支架。为此,研究人员通过将含有40 vol%玻璃颗粒和0-10 wt%石墨烯纳米薄片的浆料分散至含有乙基纤维素的乙醇中。复合支架在空气中受到可控热处理,以分解泡沫并将玻璃颗粒烧结成致密网络结构。结果显示,所施加的热处理不影响玻璃网络中石墨烯的结构。石墨烯的添加不会降低支架的力学性能,并可增强玻璃支架

在这项研究中,研究人员使用聚合物泡沫复制技术制备导电的、硼酸盐基的多孔13-93B3生物活性玻璃复合支架。为此,研究人员通过将含有40 vol%玻璃颗粒和0-10 wt%石墨烯纳米薄片的浆料分散至含有乙基纤维素的乙醇中。复合支架在空气中受到可控热处理,以分解泡沫并将玻璃颗粒烧结成致密网络结构。

结果显示,所施加的热处理不影响玻璃网络中石墨烯的结构。石墨烯的添加不会降低支架的力学性能,并可增强玻璃支架的导电性。X射线衍射分析显示,在所有样品中均可观察到对应于羟基磷灰石的结晶峰,表明在模拟体液中浸泡30天后所有样品都具有生物活性。然而,傅里叶变换红外光谱分析和扫描电子显微镜观察显示,羟基磷灰石形成速率随着石墨烯浓度的增加而降低,特别是对于在模拟体液中处理时间更短的样品。基于细胞毒性测定结果,与裸露玻璃支架相比,含有更高量石墨烯的支架可明显抑制MC3T3-E1细胞的生长。含有5wt%石墨烯的支架性能最佳,电导率提高,具有中等的细胞响应和体外羟基磷灰石形成能力。

综上所述,该研究结果表明,导电的13-93B3石墨烯支架是骨组织工程应用的有希望的候选支架。

原始出处:

Turk M, Deliormanlı AM. Electrically conductive borate-based bioactive glass scaffolds for bone tissue engineering applications. J Biomater Appl. 2017 Jul;32(1):28-39. doi: 10.1177/0885328217709608. Epub 2017 May 25.

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    2018-08-04 sunylz
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    2018-01-22 lsj630
  7. 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objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun Jan 21 13:52:52 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280674, encodeId=1a922806e459, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sun Jan 21 12:07:55 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280452, encodeId=2c8328045211, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Jan 20 20:09:37 CST 2018, time=2018-01-20, status=1, ipAttribution=)]
    2018-01-21 戒馋,懒,贪

    谢谢分享学习了

    0

  8. 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objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun Jan 21 13:52:52 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280674, encodeId=1a922806e459, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sun Jan 21 12:07:55 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280452, encodeId=2c8328045211, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Jan 20 20:09:37 CST 2018, time=2018-01-20, status=1, ipAttribution=)]
    2018-01-21 天涯183

    非常好的文章.学习了

    0

  9. 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GetPortalCommentsPageByObjectIdResponse(id=280452, encodeId=2c8328045211, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Jan 20 20:09:37 CST 2018, time=2018-01-20, status=1, ipAttribution=)]
    2018-01-21 三生有幸9135

    学习一下谢谢分享

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=280452, encodeId=2c8328045211, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Jan 20 20:09:37 CST 2018, time=2018-01-20, status=1, ipAttribution=)]
    2018-01-20 131****1460

    学习了受益匪浅

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