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CLIN CANCER RES：PHIP拷贝数作为皮肤黑色素瘤的预后及进展标志

2018-09-06 MedSci MedSci原创

黑色素瘤PHIP拷贝数预后进展
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之前的研究表明PHIP在调节黑色素瘤转移的过程中发挥了重要作用。CLIN CANCER RES近期发表了一篇文章，研究PHIP拷贝数在黑色素瘤进展中的作用。

之前的研究表明PHIP在调节黑色素瘤转移的过程中发挥了重要作用。CLIN CANCER RES近期发表了一篇文章，研究PHIP拷贝数在黑色素瘤进展中的作用。

作者在三个独立队列中利用FISH检测PHIP拷贝数，记录PHIP拷贝数≥3的细胞百分比。使用Cox回归分析研究PHIP拷贝数对患者生存的影响。在不同分子亚型的黑色素瘤中评估PHIP状态。在TCGA队列中分析PHIP表达情况。研究结果表明，PHIP拷贝数增加可以预测远处无转移生存下降和无病生存下降，以及原发黑色素瘤溃烂可能性增加。多因素分析表明，PHIP FISH评分可以独立预测远处无转移生存和无病生存。在伴有NRAS突变或表达PTEN蛋白的转移性黑色素瘤中PHIP拷贝数增加。与同一患者的原发黑色素瘤病灶相比，转移黑色素瘤PHIP拷贝数显着增加。使用TCGA队列可以重复这些关系。

文章最后认为，这些结果证明了PHIP拷贝数增加在黑色素瘤进展中的重要作用，PHIP增加可以作为黑色素瘤的分子亚型。原发灶进展为转移灶时PHIP拷贝数增加。PHIP可以作为黑色素瘤的潜在治疗靶点。

原始出处：
Vladimir Bezrookove,Mehdi Nosrati,James R.Miller,et al.Role of Elevated PHIP Copy Number as a Prognostic and Progression Marker for Cutaneous Melanoma.CLIN CANCER RES.September 2018 doi:10.1158/1078-0432.CCR-18-0791

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    2018-11-03 sunylz

    #色素#

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    2019-04-28 bsmagic9132

    #拷贝数#

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    2019-08-10 zhu_jun9837

    #PHIP拷贝数#

    0

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encryptionId=e9dc14192c7, topicName=PHIP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Mon Jul 22 17:14:00 CST 2019, time=2019-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344866, encodeId=ad4e344866fa, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Sep 13 21:04:59 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344169, encodeId=36eb34416969, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Sep 09 13:11:40 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1436009, encodeId=80ed143600969, content=<a href='/topic/show?id=c38de2137e4' target=_blank style='color:#2F92EE;'>#皮肤黑色素瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72137, encryptionId=c38de2137e4, topicName=皮肤黑色素瘤)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Sep 08 11:14:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558922, encodeId=075a1558922ef, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Sep 08 11:14:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564931, encodeId=8d00156493138, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Sep 08 11:14:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343399, encodeId=d8cb343399e7, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Sep 07 08:39:52 CST 2018, time=2018-09-07, status=1, ipAttribution=)]
    2019-07-22 medscijoin

    #PHIP#

    0

  5. 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createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Sep 08 11:14:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343399, encodeId=d8cb343399e7, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Sep 07 08:39:52 CST 2018, time=2018-09-07, status=1, ipAttribution=)]
    2018-09-13 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

  6. 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createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Sep 08 11:14:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343399, encodeId=d8cb343399e7, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Sep 07 08:39:52 CST 2018, time=2018-09-07, status=1, ipAttribution=)]
    2018-09-09 wxl882001

    学习一下

    0

  7. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Sep 09 13:11:40 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1436009, encodeId=80ed143600969, content=<a href='/topic/show?id=c38de2137e4' target=_blank style='color:#2F92EE;'>#皮肤黑色素瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72137, encryptionId=c38de2137e4, topicName=皮肤黑色素瘤)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Sep 08 11:14:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558922, encodeId=075a1558922ef, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Sep 08 11:14:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564931, encodeId=8d00156493138, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Sep 08 11:14:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343399, encodeId=d8cb343399e7, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Sep 07 08:39:52 CST 2018, time=2018-09-07, status=1, ipAttribution=)]
    2018-09-08 zhouqu_8

    #皮肤黑色素瘤#

    0

  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Sep 09 13:11:40 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1436009, encodeId=80ed143600969, content=<a href='/topic/show?id=c38de2137e4' target=_blank style='color:#2F92EE;'>#皮肤黑色素瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72137, encryptionId=c38de2137e4, topicName=皮肤黑色素瘤)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Sep 08 11:14:00 CST 2018, time=2018-09-08, status=1, 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createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Sep 08 11:14:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343399, encodeId=d8cb343399e7, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Sep 07 08:39:52 CST 2018, time=2018-09-07, status=1, ipAttribution=)]
    2018-09-08 cqlidoudou

    #黑色素#

    0

  9. 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createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sat Sep 08 11:14:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343399, encodeId=d8cb343399e7, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Sep 07 08:39:52 CST 2018, time=2018-09-07, status=1, ipAttribution=)]
    2018-09-08 cqlidoudou

    #黑色素#

    0

  10. 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    2018-09-07 kafei

    学习了谢谢

    0

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