2015高血压年会:孙宁玲教授--如何用叶酸治疗高Hcy高血压患者(CSPPT研究)

2015-09-22 MedSci MedSci原创

孙宁玲教授是北京大学人民医院心血管专业高血压病房主任、高血压研究室主任。孙教授长期从事心血管高血压专业方面的工作,在高血压、高血脂及心血管心功能方面进行了系统的临床及实验性研究。在9月18日的2015高血压年会上,孙教授介绍了她和霍勇教授牵头进行的CSPPT研究的研究报告,在报告结束后,MedSci非常荣幸采访到了孙宁玲教授,以下是采访的内容:MedSci:孙教授,您好!您刚刚在大会上对CSPPT

孙宁玲教授是北京大学人民医院心血管专业高血压病房主任、高血压研究室主任。孙教授长期从事心血管高血压专业方面的工作,在高血压、高血脂及心血管心功能方面进行了系统的临床及实验性研究。


在9月18日的2015高血压年会上,孙教授介绍了她和霍勇教授牵头进行的CSPPT研究的研究报告,在报告结束后,MedSci非常荣幸采访到了孙宁玲教授,以下是采访的内容:




MedSci:孙教授,您好!您刚刚在大会上对CSPPT研究的报告内容非常精彩,关于CSPPT研究,您能介绍一下叶酸治疗高同型半胱氨酸高血压在临床上的具体应用方法么?


孙宁玲:单纯的Hcy增高不会造成太大的风险,但是高血压合并高Hcy会有较大的卒中风险。因此,在高血压患者预防卒中的过程中,首先降压;然后考虑患者是否有Hcy增高,如果存在高Hcy,那么就补充叶酸。


叶酸的基本补充量是0.8mg。0.8mg的叶酸会比5mg或者更多剂量的叶酸在治疗高Hcy高血压方面有着更好的作用,因为5mg剂量的叶酸是可以在社会上买到的,但是长期大量服用会产生肿瘤风险,所以我们要保证低剂量的、可持续使用剂量的叶酸进行补充,一般呢叶酸都是和降压药来进行联合用药。我们现在临床上常用药就是依叶片,依叶片就是依那普利再加上叶酸。以后还会研制出氨氯地平叶酸片,但是他们的叶酸的剂量都是0.8mg。


MedSci:谢谢孙教授的介绍,CSPPT研究对高血压的防治具有重要意义,您本人在临床和科研方面都有很大的成就。那么,您对年轻的临床医生的继续学习和科研有什么指导?


孙宁玲:对临床医生来说,第一重要的便是实践,医生的医学知识的提高基于临床实践,就是说在实践的基础上不断地学习临床知识,这个过程包括实验。实验就是做临床试验,搞科研就是把临床知识跟实验结合起来,进而提高临床知识。所以,我希望年轻的临床医生们:第一、先踏踏实实地把临床基础打好,做一个能够处理好临床各种疾病的医生;然后,在这个基础上,把更多的时间投入到科学研究中,这种科学研究是医生的临床实践得以提高的保证。


医生读不读研究生是不一样的,读了研究生,他肯定有科研实践的能力,研究生可以把临床的需求与科学的病理、生理机制很快得结合起来,再根据临床需求,再进一步地做科研,这样就会提高地很快。但是纯粹的、单一的、没有科研背景的临床医生在医学生涯中前进的步伐会受到影响,所以,我们希望临床医生能够把更多的精力投入到学习中去。当然,有效地生活,管理好生活中的方方面面也是必要的。光阴易逝,不要等到时间一天天过去了,才开始后悔。在有限的时间里更好地完善自己,一个优秀的医生应该付出更多的精力。


MedSci:谢谢孙教授对年轻临床医生的教诲。孙教授,最后想问您一个问题,作为一名临床医生中的专家,您对像MedSci这样的医学媒体有着怎样的寄语?


孙宁玲:医学媒体首先要把医学与媒体相结合,要了解医生需要什么,能给医生提供什么,这种提供是医生需要的么,而不是自说自话。许多时候媒体觉得有用,但是医生却会觉得没用。但是,像文献的检索、临床证据的提供、论文之后的技术支持的提供等等,这些都是临床医生所不熟悉,或者有所欠缺的。我知道你们MedSci,你们早先时候是进行文章的翻译,但是,你们现在进行了许多功能的改进,不仅仅在修改文章,也在推动学术的发展。因此,希望你们能够多多参与这样的会议,主动地去做工作,了解更多的医学信息,把这些知识传递给临床医生们。


MedSci:非常感谢孙教授接受我们的采访,祝您参会愉快!


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    2016-01-15 1dde3d0fm38(暂无匿称)

    期待推广治疗

    0

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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Fri Oct 02 03:39:00 CST 2015, time=2015-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448146, encodeId=b9721448146db, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Thu Sep 24 00:39:00 CST 2015, time=2015-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37200, encodeId=45c73e20070, content=解读EMPA-REG OUTCOME研究 作者:河北省人民医院 郭艺芳 在2015年EASD年会期间,揭晓了举世瞩目的降糖治疗试验EMPA-REG OUTCOME研究结果。, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Wed Sep 23 22:07:00 CST 2015, time=2015-09-23, status=1, ipAttribution=)]
    2016-08-12 huiwelcome
  4. 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Fri Oct 02 03:39:00 CST 2015, time=2015-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448146, encodeId=b9721448146db, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Thu Sep 24 00:39:00 CST 2015, time=2015-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37200, encodeId=45c73e20070, content=解读EMPA-REG OUTCOME研究 作者:河北省人民医院 郭艺芳 在2015年EASD年会期间,揭晓了举世瞩目的降糖治疗试验EMPA-REG OUTCOME研究结果。, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Wed Sep 23 22:07:00 CST 2015, time=2015-09-23, status=1, ipAttribution=)]
    2015-10-25 hlycom3356

    这篇文章写得非常好

    0

  5. 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Fri Oct 02 03:39:00 CST 2015, time=2015-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448146, encodeId=b9721448146db, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Thu Sep 24 00:39:00 CST 2015, time=2015-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37200, encodeId=45c73e20070, content=解读EMPA-REG OUTCOME研究 作者:河北省人民医院 郭艺芳 在2015年EASD年会期间,揭晓了举世瞩目的降糖治疗试验EMPA-REG OUTCOME研究结果。, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Wed Sep 23 22:07:00 CST 2015, time=2015-09-23, status=1, ipAttribution=)]
    2015-10-25 hlycom3356

    这篇文章写得非常好

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1947514, encodeId=f024194e5146a, content=<a href='/topic/show?id=360f14591e2' target=_blank style='color:#2F92EE;'>#PPT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14591, encryptionId=360f14591e2, topicName=PPT)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Mon Oct 19 06:39:00 CST 2015, time=2015-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57571, encodeId=add45e571e9, content=期待推广治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Fri Oct 02 03:39:00 CST 2015, time=2015-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448146, encodeId=b9721448146db, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Thu Sep 24 00:39:00 CST 2015, time=2015-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37200, encodeId=45c73e20070, content=解读EMPA-REG OUTCOME研究 作者:河北省人民医院 郭艺芳 在2015年EASD年会期间,揭晓了举世瞩目的降糖治疗试验EMPA-REG OUTCOME研究结果。, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Wed Sep 23 22:07:00 CST 2015, time=2015-09-23, status=1, ipAttribution=)]
    2015-10-25 hlycom3356

    这篇文章写得非常好

    0

  7. 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Fri Oct 02 03:39:00 CST 2015, time=2015-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448146, encodeId=b9721448146db, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Thu Sep 24 00:39:00 CST 2015, time=2015-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37200, encodeId=45c73e20070, content=解读EMPA-REG OUTCOME研究 作者:河北省人民医院 郭艺芳 在2015年EASD年会期间,揭晓了举世瞩目的降糖治疗试验EMPA-REG OUTCOME研究结果。, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Wed Sep 23 22:07:00 CST 2015, time=2015-09-23, status=1, ipAttribution=)]
    2015-10-25 hlycom3356

    这篇文章写得非常好

    0

  8. 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Fri Oct 02 03:39:00 CST 2015, time=2015-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448146, encodeId=b9721448146db, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Thu Sep 24 00:39:00 CST 2015, time=2015-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37200, encodeId=45c73e20070, content=解读EMPA-REG OUTCOME研究 作者:河北省人民医院 郭艺芳 在2015年EASD年会期间,揭晓了举世瞩目的降糖治疗试验EMPA-REG OUTCOME研究结果。, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Wed Sep 23 22:07:00 CST 2015, time=2015-09-23, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1947514, encodeId=f024194e5146a, content=<a href='/topic/show?id=360f14591e2' target=_blank style='color:#2F92EE;'>#PPT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14591, encryptionId=360f14591e2, topicName=PPT)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Mon Oct 19 06:39:00 CST 2015, time=2015-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57571, encodeId=add45e571e9, content=期待推广治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdName=hlycom3356, createdTime=Sun Oct 25 10:04:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40912, encodeId=5ebc40912a9, content=这篇文章写得非常好, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 25 10:04:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077266, encodeId=68a520e726623, content=<a href='/topic/show?id=2716535631' target=_blank style='color:#2F92EE;'>#CSP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5356, encryptionId=2716535631, topicName=CSP)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Fri Oct 02 03:39:00 CST 2015, time=2015-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448146, encodeId=b9721448146db, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Thu Sep 24 00:39:00 CST 2015, time=2015-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37200, encodeId=45c73e20070, content=解读EMPA-REG OUTCOME研究 作者:河北省人民医院 郭艺芳 在2015年EASD年会期间,揭晓了举世瞩目的降糖治疗试验EMPA-REG OUTCOME研究结果。, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Wed Sep 23 22:07:00 CST 2015, time=2015-09-23, status=1, ipAttribution=)]
  10. 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在2015年EASD年会期间,揭晓了举世瞩目的降糖治疗试验EMPA-REG OUTCOME研究结果。, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Wed Sep 23 22:07:00 CST 2015, time=2015-09-23, status=1, ipAttribution=)]
    2015-09-23 x35042875

    解读EMPA-REG OUTCOME研究 作者:河北省人民医院 郭艺芳 在2015年EASD年会期间,揭晓了举世瞩目的降糖治疗试验EMPA-REG OUTCOME研究结果。

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