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SCTM:人类肾脏祖细胞分离为细胞再生提供新线索

2016-09-14 佚名 生物谷

细胞分离
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近日，洛杉矶儿童医院萨班研究所的研究员分离出了人类肾元祖细胞(NP)。他们的研究结果发表在《Stem Cell Translational Medicine》杂志上，这将帮助科学家们了解发育中的胎儿体内的这些祖细胞如何分化成为肾细胞，并可能在未来的慢性肾功能衰竭或急性损伤后提供一种治疗方式促进肾再生。 肾脏的关键部位——肾单元是一种微小的结构，它可以过滤废物。在孕妇妊娠期34周到36周的胎儿体内

近日，洛杉矶儿童医院萨班研究所的研究员分离出了人类肾元祖细胞(NP)。他们的研究结果发表在《Stem Cell Translational Medicine》杂志上，这将帮助科学家们了解发育中的胎儿体内的这些祖细胞如何分化成为肾细胞，并可能在未来的慢性肾功能衰竭或急性损伤后提供一种治疗方式促进肾再生。

肾脏的关键部位——肾单元是一种微小的结构，它可以过滤废物。在孕妇妊娠期34周到36周的胎儿体内大约有500，000到1000，000个肾单元生成，NP细胞在这个时期会完全耗竭，之后肾生成就会停止。在这个时期之后的任何时间内都可能会有大量的肾单元损失，从而导致不可逆的肾功能衰竭，进而不能进行进一步的细胞修复或再生。

此前，在动物模型中的肾元祖细胞主要是用来研究使用诱导多能干细胞(ipc)。洛杉矶儿童医院的科学家使用RNA标记探针直接分离人类NP细胞获取NP细胞表达的SIX2和CITED1——这个基因调节肾脏的发育。

“除了定义人类NP细胞的基因档案，该系统将促进人类肾脏发育的研究，它为肾再生和生物工程提供了一个新的工具。”Laura Perin博士说。

研究人员可以将这项技术用于其他器官中，如胰腺或肺中。“这是一个重要的工具，它能够帮助科学家研究人类细胞的细胞再生和分化。”Stefano Da Sacco说。

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    2016-09-25 1e0ece0dm09(暂无匿称)

    学习了谢谢

    0

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    2016-09-16 12498636m52(暂无昵称)

    #祖细胞#

    0

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    2016-09-15 1dd8a7c5m95(暂无匿称)

    学习了，赞一个！！！

    0

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    2016-09-15 1dd8a7c5m95(暂无匿称)

    学习了，赞一个！！！

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=134630, encodeId=ff9f13463099, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Sun Sep 25 00:22:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512417, encodeId=735c151241e42, content=<a href='/topic/show?id=f802e4102cb' target=_blank style='color:#2F92EE;'>#祖细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74102, encryptionId=f802e4102cb, topicName=祖细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f18310470858, createdName=12498636m52(暂无昵称), createdTime=Fri Sep 16 06:06:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128041, encodeId=288a1280419b, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Sep 15 17:39:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=127786, encodeId=895c12e7863f, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Sep 15 15:35:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=127667, encodeId=1b5612e66743, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Sep 15 14:52:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=126970, encodeId=a5f41269e0df, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Sep 14 22:04:00 CST 2016, time=2016-09-14, status=1, ipAttribution=)]
    2016-09-15 1dd8a7c5m95(暂无匿称)

    学习了，赞一个！！！

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=134630, encodeId=ff9f13463099, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Sun Sep 25 00:22:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512417, encodeId=735c151241e42, content=<a href='/topic/show?id=f802e4102cb' target=_blank style='color:#2F92EE;'>#祖细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74102, encryptionId=f802e4102cb, topicName=祖细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f18310470858, createdName=12498636m52(暂无昵称), createdTime=Fri Sep 16 06:06:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128041, encodeId=288a1280419b, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Sep 15 17:39:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=127786, encodeId=895c12e7863f, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Sep 15 15:35:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=127667, encodeId=1b5612e66743, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Sep 15 14:52:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=126970, encodeId=a5f41269e0df, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Sep 14 22:04:00 CST 2016, time=2016-09-14, status=1, ipAttribution=)]
    2016-09-14 1dd8a7c5m95(暂无匿称)

    学习了，赞一个！！！

    0