Radiology:肝转移瘤90Y放射性栓塞治疗后评估用PET/CT好还是MRI好?

2018-07-27 shaosai MedSci原创

本研究旨在验证钇90(90Y)治疗后4-6周扩散加权肝脏磁共振(MR)图像与PET/CT或影响生存期的肿瘤指标间的关系,并将结果发表在Radiology上。

本研究旨在验证钇90(90Y)治疗后4-6周扩散加权肝脏磁共振(MR)图像与PET/CT或影响生存期的肿瘤指标间的关系,并将结果发表在Radiology上。

本研究共纳入了36例肝转移瘤并与90Y放射性栓塞治疗后4-6周行氟18 (18F)氟脱氧葡萄糖(FDG)PET/CT及DW MRI的患者。DW MRI反应定义为平均最小表观扩散系数增加超过30%;PET/CT定义为平均最大标准摄入量降低超过30%。利用Kaplan-Meier曲线、log等级检验、多变量Cox回归分析比较功能影像学检查表现患者生存情况与TECIST反应、治疗前ECOG效果(PS) (0 vs 1)、肝肿瘤负荷(<25% vs ≥25%)和有无肝外病变。

结果为,对35/36例患者随访到死亡(中位生存期为36周)。共有18/36例患者PET/CT上出现反应(50%)。在有无PET/CT反应的患者中中位生存期分别为39周、27周(P = .60)。共有24/36例患者PET/CT上出现反应(67%)。在有无DW MRI反应的患者中中位生存期分别为53周、20周(P = .60) (P = .01)。在多变量分析中,DW MRI是唯一能够预测生存期的指标(P < .01)。基于RECIST指标、ECOG PS、肿瘤负荷和出现肝外病变均与生存期无明显相关性。

本研究表明,对于行 90Y放射学栓塞治疗的肝转移瘤患者,DW MRI预测治疗反应要优于PET/CT及肿瘤指标。

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    2019-03-25 feather89
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    2018-09-22 jyzxjiangqin

    肝转移瘤患者的治疗。

    0

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    2018-09-11 jyzxjiangqin

    肝转移瘤患者的治疗。

    0

  4. 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href='/topic/show?id=6b058150307' target=_blank style='color:#2F92EE;'>#肝转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81503, encryptionId=6b058150307, topicName=肝转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea155117075, createdName=ms6747015003810650, createdTime=Sun Jul 29 04:09:00 CST 2018, time=2018-07-29, status=1, ipAttribution=)]
    2018-08-29 jyzxjiangqin

    肝转移瘤治疗靶向药物。

    0

  5. 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09:31:26 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344557, encodeId=9c9b34455e67, content=肝转移瘤患者的治疗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Sep 11 21:31:42 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341661, encodeId=c47034166164, content=肝转移瘤治疗靶向药物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Aug 29 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Sun Jul 29 04:09:00 CST 2018, time=2018-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331103, encodeId=21f613311033b, content=<a href='/topic/show?id=15e2140e438' target=_blank style='color:#2F92EE;'>#PET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5PdY90y5Jib8FnPhCXTR2d9v3K17epNSwB2eb0vmXUldNJl2e72S4unZTAHLAojicdVSialTDFHAxA/132, createdBy=78d82500042, createdName=ms7514935887898259, createdTime=Sun Jul 29 04:09:00 CST 2018, time=2018-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443836, encodeId=6375144383696, content=<a href='/topic/show?id=6b058150307' target=_blank style='color:#2F92EE;'>#肝转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81503, encryptionId=6b058150307, topicName=肝转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea155117075, createdName=ms6747015003810650, createdTime=Sun Jul 29 04:09:00 CST 2018, time=2018-07-29, status=1, ipAttribution=)]
    2018-08-17 jyzxjiangqin

    肝转移瘤治疗的手术。

    0

  6. 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  7. 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href='/topic/show?id=6b058150307' target=_blank style='color:#2F92EE;'>#肝转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81503, encryptionId=6b058150307, topicName=肝转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea155117075, createdName=ms6747015003810650, createdTime=Sun Jul 29 04:09:00 CST 2018, time=2018-07-29, status=1, ipAttribution=)]
    2018-08-05 jyzxjiangqin

    肝转移瘤治疗。

    0

  8. 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