JAMA Psychiatry:孕期吸烟与后代严重精神病

2017-05-05 zhangfan MedSci原创

人口和家庭为基础的研究表明,怀孕期间吸烟与后代严重的精神疾病风险间并无显著的统计学关联

最近几项以人群为基础的研究表明孕期母亲暴露于吸烟环境会增加后代严重精神疾病的风险(例如,双相情感障碍,精神分裂症)。然而,目前还不清楚这种关联是因果致畸效应还是后代成长过程中吸烟诱发严重精神疾病所引起的。近日研究人员就怀孕期间吸烟和后代严重的精神疾病之间的关系进行研究

研究收集分析了1983年至2001年1680219新生儿的资料,对在怀孕期间吸烟和严重的精神疾病的后代之间的关联进行估计。同时研究者还将吸烟与家庭成员内部发生精神疾病进行统计,检测的家族遗传和环境因素对新生儿精神病的影响。

研究中涉及的新生儿中,816775名(48.61%)为女性。在总人口水平,怀孕期间暴露于中高度水平吸烟环境的后代有更高的严重心理疾病发病率(孕期中度吸烟风险比1.25,95% CI 1.19-1.30;孕期高度吸烟风险比1.51,95% CI 1.44-1.59)与先前研究结果一致,但将上述结果通过家族环境因素调整后,其风险比降低,家庭内协变量调整发现吸烟导致的后代严重精神病风险大幅减低,缺少统计学意义(孕期中度吸烟风险比1.09,95% CI 0.94-1.26;孕期高度吸烟风险比1.14,95% CI 0.96-1.35)。

尽管吸烟对于后代有种种不利因素,但这项以人口和家庭为基础的研究表明,怀孕期间吸烟与后代严重的精神疾病风险间并无显著的统计学关联。

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    2017-05-06 lusee

    学习了,谢谢分享。

    0

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    2017-05-05 胖红

    学习了很多的事情

    0

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    2017-05-05 三生有幸9135

    学习一下谢谢分享

    0

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    2017-05-05 sy3923582

    不错哦,学习了

    0

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