Metabolism:腹肌面积和密度与冠状动脉钙化体积和密度的关系

2020-04-20 MedSci原创 MedSci原创

AMA和AMD与CAC体积和密度有不同的关联,AMA与较高风险的CAC(高体积,低密度)显著相关,而AMD与CAC体积或密度没有显著相关性。未来的研究需要考虑肌肉成分和CAC的独特组分。

由于冠状动脉钙化(CAC)的体积和密度与心血管风险相反,近日,代谢性疾病领域权威杂志Metabolism-Clinical and Experimental上发表了一篇研究文章,研究人员旨在检验以下假设:即腹肌面积(AMA)和密度(AMD)增加与较低的冠状动脉钙(CAC)体积和较高的CAC密度相关。

研究人员使用来自多民族动脉粥样硬化研究中身体成分研究的787名参与者的数据,并分析了参与者的腹部和胸部CT扫描。通过腹部扫描记录了肌肉面积、肌肉密度(衰减)以及内脏和皮下脂肪。通过胸部扫描确定了CAC体积和Agatston值,以得到CAC密度评分。

参与者的平均(SD)年龄和BMI分别为67.8(9.0)岁和27.9(4.8)kg/m 2。女性为41%,白人为46%,高血压为60%,糖尿病为17%,血脂异常为46%。AMA与CAC体积呈正相关(p<0.001),与CAC密度呈负相关(p<0.001)。相反,在最小调整模型中,AMD与CAC体积呈负相关,而与CAC密度呈正相关(p<0.001),但在混杂变量调整模型中则不显著。

由此可见,AMA和AMD与CAC体积和密度有不同的关联,AMA与较高风险的CAC(高体积,低密度)显著相关,而AMD与CAC体积或密度没有显著相关性。未来的研究需要考虑肌肉成分和CAC的独特组分。

原始出处:

Margaret A. Crawford,et al.Associations of abdominal muscle area and density with coronary artery calcium volume and density: the multi-ethnic study of atherosclerosis.Metabolism-Clinical and Experimental.2020.https://www.metabolismjournal.com/article/S0026-0495(20)30094-9/fulltext

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    2020-10-01 guojianrong
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    2020-10-23 一闲
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    2020-04-22 闆锋旦